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Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab

BACKGROUND: Recent studies have demonstrated that T cells can induce vasodilation in a choline-acetyltransferase dependent manner, leading to an increase in T cell migration to infected tissues in response to viral infection, but its role in cancer is unclear. Choline acetyltransferase catalyzes the...

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Detalles Bibliográficos
Autores principales:	Watson, Geoffrey Alan, Sanz-Garcia, Enrique, Zhang, Wen-Jiang, Liu, Zhihui Amy, Yang, SY Cindy, Wang, Ben, Liu, Shaofeng, Kubli, Shawn, Berman, Hal, Pfister, Thomas, Genta, Sofia, Spreafico, Anna, Hansen, Aaron R, Bedard, Philippe L, Lheureux, Stephanie, Abdul Razak, Albiruni, Cescon, Dave, Butler, Marcus O, Xu, Wei, Mak, Tak W, Siu, Lillian L, Chen, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Immunotherapy Biomarkers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204435/ https://www.ncbi.nlm.nih.gov/pubmed/35705312 http://dx.doi.org/10.1136/jitc-2021-004378

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