Cadmium(II) compounds of the bis-cyanoethyl derivative (L(CX)) of Me(8)[14]aneC (L(C)): characterization and antibacterial studies

The isomeric ligand L(C), a saturated analogue of 2,9-C-meso-Me(8)[14]diene, on reflux with excess acrylonitrile afforded 1,8-N-pendant cyanoethyl derivative L(CX). Interaction of L(CX) with cadmium(II) perchlorate, nitrate, acetate, and chloride salts produced six coordinated octahedral compounds, [Cd(L(CX)) (ClO(4))(2)]∙2H(2)O, [Cd(L(CX)) (NO(3))(2)], [Cd(L(CX)) (CH(3)COO)(2)], and [Cd(L(CX))Cl(2)], respectively. Further, axial substitution reactions between [Cd(L(CX)) (ClO(4))(2)]∙2H(2)O and KI, KBr, KCl, KSCN, and NaNO(2) in a 1:2 ratio yielded six coordinated octahedral compounds, [Cd(L(CX))I(2)]∙H(2)O, [Cd(L(CX))Br(2)]∙2H(2)O, [Cd(L(CX))Cl(ClO(4))]∙2H(2)O, [Cd(L(CX)) (NCS)(2)]∙H(2)O, and [Cd(L(CX)) (NO(2)) (ClO(4))]∙2H(2)O, respectively. All of the newly prepared compounds have been characterized by analytical, spectroscopic, molar conductivity, and magnetochemical data. The crystal structure of the ligand L(CX) was determined by x-ray crystallography which showed the 14-membered ring to adopt an extended chair conformation. Antibacterial activities of the newly formed cadmium(II) complexes against selected bacteria showed these to exhibit moderate and selective activity with 1-4 and 8 exhibiting greatest potency against the gram negative bacterium Salmonella typhi, and 5, 6, and 7 against the gram positive bacterium Bacillus wiedmannii.