Stoichiometry-Selective Antagonism of α4β2 Nicotinic Acetylcholine Receptors by Fluoroquinolone Antibiotics

[Image: see text] Quinolone antibiotics disrupt bacterial DNA synthesis by interacting with DNA gyrase and topoisomerase IV. However, in addition, they have been shown to act as inhibitors of pentameric ligand-gated ion channels such as GABA(A) receptors and the α7 nicotinic acetylcholine receptor (...

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Detalles Bibliográficos
Autores principales: Sanders, Victoria R., Sweeney, Aaron, Topf, Maya, Millar, Neil S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204775/
https://www.ncbi.nlm.nih.gov/pubmed/35657695
http://dx.doi.org/10.1021/acschemneuro.2c00200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204775/
https://www.ncbi.nlm.nih.gov/pubmed/35657695
http://dx.doi.org/10.1021/acschemneuro.2c00200

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