2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains

[Image: see text] Small-molecule fluorescent stains enable the imaging of cellular structures without the need for genetic manipulation. Here, we introduce 2,7-diaminobenzopyrylium (DAB) dyes as live-cell mitochondrial stains excited with violet light. This amalgam of the coumarin and rhodamine fluo...

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Autores principales: Banala, Sambashiva, Tkachuk, Ariana N., Patel, Ronak, Kumar, Pratik, Brown, Timothy A., Lavis, Luke D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204777/
https://www.ncbi.nlm.nih.gov/pubmed/35726328
http://dx.doi.org/10.1021/acsbiomedchemau.1c00068
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author Banala, Sambashiva
Tkachuk, Ariana N.
Patel, Ronak
Kumar, Pratik
Brown, Timothy A.
Lavis, Luke D.
author_facet Banala, Sambashiva
Tkachuk, Ariana N.
Patel, Ronak
Kumar, Pratik
Brown, Timothy A.
Lavis, Luke D.
author_sort Banala, Sambashiva
collection PubMed
description [Image: see text] Small-molecule fluorescent stains enable the imaging of cellular structures without the need for genetic manipulation. Here, we introduce 2,7-diaminobenzopyrylium (DAB) dyes as live-cell mitochondrial stains excited with violet light. This amalgam of the coumarin and rhodamine fluorophore structures yields dyes with high photostability and tunable spectral properties.
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spelling pubmed-92047772022-06-18 2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains Banala, Sambashiva Tkachuk, Ariana N. Patel, Ronak Kumar, Pratik Brown, Timothy A. Lavis, Luke D. ACS Bio Med Chem Au [Image: see text] Small-molecule fluorescent stains enable the imaging of cellular structures without the need for genetic manipulation. Here, we introduce 2,7-diaminobenzopyrylium (DAB) dyes as live-cell mitochondrial stains excited with violet light. This amalgam of the coumarin and rhodamine fluorophore structures yields dyes with high photostability and tunable spectral properties. American Chemical Society 2022-02-28 /pmc/articles/PMC9204777/ /pubmed/35726328 http://dx.doi.org/10.1021/acsbiomedchemau.1c00068 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Banala, Sambashiva
Tkachuk, Ariana N.
Patel, Ronak
Kumar, Pratik
Brown, Timothy A.
Lavis, Luke D.
2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains
title 2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains
title_full 2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains
title_fullStr 2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains
title_full_unstemmed 2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains
title_short 2,7-Diaminobenzopyrylium Dyes Are Live-Cell Mitochondrial Stains
title_sort 2,7-diaminobenzopyrylium dyes are live-cell mitochondrial stains
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204777/
https://www.ncbi.nlm.nih.gov/pubmed/35726328
http://dx.doi.org/10.1021/acsbiomedchemau.1c00068
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