Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth

BACKGROUND: Targeting AKT suppresses tumor growth through inducing apoptosis, however, during which whether other forms of cell death occurring is poorly understood. METHODS: The effects of increasing PARP1 dependent cell death (parthanatos) induced by inhibiting AKT on cell proliferation were deter...

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Detalles Bibliográficos
Autores principales: Zhang, Yizheng, Zhang, Chuchu, Li, Jiehan, Jiang, Meimei, Guo, Shuning, Yang, Ge, Zhang, Lingling, Wang, Feng, Yi, Shiqi, Wang, Jiangang, Fu, Yang, Zhang, Yingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205131/
https://www.ncbi.nlm.nih.gov/pubmed/35715817
http://dx.doi.org/10.1186/s12964-022-00897-1

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