Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022

We describe a gonorrhoea case with ceftriaxone plus high-level azithromycin resistance. In April 2022, an Austrian heterosexual male was diagnosed with gonorrhoea after sexual intercourse with a female sex worker in Cambodia. Recommended treatment with ceftriaxone (1 g) plus azithromycin (1.5 g) pos...

Descripción completa

Detalles Bibliográficos
Autores principales: Pleininger, Sonja, Indra, Alexander, Golparian, Daniel, Heger, Florian, Schindler, Stefanie, Jacobsson, Susanne, Heidler, Stefan, Unemo, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2022
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205165/
https://www.ncbi.nlm.nih.gov/pubmed/35713023
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.24.2200455
_version_ 1784729072385916928
author Pleininger, Sonja
Indra, Alexander
Golparian, Daniel
Heger, Florian
Schindler, Stefanie
Jacobsson, Susanne
Heidler, Stefan
Unemo, Magnus
author_facet Pleininger, Sonja
Indra, Alexander
Golparian, Daniel
Heger, Florian
Schindler, Stefanie
Jacobsson, Susanne
Heidler, Stefan
Unemo, Magnus
author_sort Pleininger, Sonja
collection PubMed
description We describe a gonorrhoea case with ceftriaxone plus high-level azithromycin resistance. In April 2022, an Austrian heterosexual male was diagnosed with gonorrhoea after sexual intercourse with a female sex worker in Cambodia. Recommended treatment with ceftriaxone (1 g) plus azithromycin (1.5 g) possibly failed. Worryingly, this is the second strain in an Asian Neisseria gonorrhoeae genomic sublineage including high-level azithromycin-resistant strains that developed ceftriaxone resistance by acquisition of mosaic penA-60.001. Enhanced resistance surveillance and actions are imperative to prevent spread.
format Online
Article
Text
id pubmed-9205165
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher European Centre for Disease Prevention and Control (ECDC)
record_format MEDLINE/PubMed
spelling pubmed-92051652022-06-27 Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022 Pleininger, Sonja Indra, Alexander Golparian, Daniel Heger, Florian Schindler, Stefanie Jacobsson, Susanne Heidler, Stefan Unemo, Magnus Euro Surveill Rapid Communication We describe a gonorrhoea case with ceftriaxone plus high-level azithromycin resistance. In April 2022, an Austrian heterosexual male was diagnosed with gonorrhoea after sexual intercourse with a female sex worker in Cambodia. Recommended treatment with ceftriaxone (1 g) plus azithromycin (1.5 g) possibly failed. Worryingly, this is the second strain in an Asian Neisseria gonorrhoeae genomic sublineage including high-level azithromycin-resistant strains that developed ceftriaxone resistance by acquisition of mosaic penA-60.001. Enhanced resistance surveillance and actions are imperative to prevent spread. European Centre for Disease Prevention and Control (ECDC) 2022-06-16 /pmc/articles/PMC9205165/ /pubmed/35713023 http://dx.doi.org/10.2807/1560-7917.ES.2022.27.24.2200455 Text en This article is copyright of the authors or their affiliated institutions, 2022. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Pleininger, Sonja
Indra, Alexander
Golparian, Daniel
Heger, Florian
Schindler, Stefanie
Jacobsson, Susanne
Heidler, Stefan
Unemo, Magnus
Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022
title Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022
title_full Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022
title_fullStr Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022
title_full_unstemmed Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022
title_short Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022
title_sort extensively drug-resistant (xdr) neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in austria, april 2022
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205165/
https://www.ncbi.nlm.nih.gov/pubmed/35713023
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.24.2200455
work_keys_str_mv AT pleiningersonja extensivelydrugresistantxdrneisseriagonorrhoeaecausingpossiblegonorrhoeatreatmentfailurewithceftriaxoneplusazithromycininaustriaapril2022
AT indraalexander extensivelydrugresistantxdrneisseriagonorrhoeaecausingpossiblegonorrhoeatreatmentfailurewithceftriaxoneplusazithromycininaustriaapril2022
AT golpariandaniel extensivelydrugresistantxdrneisseriagonorrhoeaecausingpossiblegonorrhoeatreatmentfailurewithceftriaxoneplusazithromycininaustriaapril2022
AT hegerflorian extensivelydrugresistantxdrneisseriagonorrhoeaecausingpossiblegonorrhoeatreatmentfailurewithceftriaxoneplusazithromycininaustriaapril2022
AT schindlerstefanie extensivelydrugresistantxdrneisseriagonorrhoeaecausingpossiblegonorrhoeatreatmentfailurewithceftriaxoneplusazithromycininaustriaapril2022
AT jacobssonsusanne extensivelydrugresistantxdrneisseriagonorrhoeaecausingpossiblegonorrhoeatreatmentfailurewithceftriaxoneplusazithromycininaustriaapril2022
AT heidlerstefan extensivelydrugresistantxdrneisseriagonorrhoeaecausingpossiblegonorrhoeatreatmentfailurewithceftriaxoneplusazithromycininaustriaapril2022
AT unemomagnus extensivelydrugresistantxdrneisseriagonorrhoeaecausingpossiblegonorrhoeatreatmentfailurewithceftriaxoneplusazithromycininaustriaapril2022

Ejemplares similares