A Phase 1 Proof of Concept Study Evaluating the Addition of an LSD1 Inhibitor to Nab-Paclitaxel in Advanced or Metastatic Breast Cancer (EPI-PRIMED)

OBJECTIVE: Lysine-Specific Demethylase-1 (LSD1) is overexpressed in breast cancer cells and facilitate mesenchymal properties which may contribute to therapeutic resistance and cancer progression. The purpose of this study was to investigate the safety of combination, nab-paclitaxel and phenelzine,...

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Detalles Bibliográficos
Autores principales: Prasanna, Thiru, Malik, Laeeq, McCuaig, Robert D., Tu, Wen Juan, Wu, Fan, Lim, Pek Siew, Tan, Abel H. Y., Dahlstrom, Jane E., Clingan, Philip, Moylan, Eugene, Chrisp, Jeremy, Fuller, David, Rao, Sudha, Yip, Desmond
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205212/
https://www.ncbi.nlm.nih.gov/pubmed/35719960
http://dx.doi.org/10.3389/fonc.2022.862427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205212/
https://www.ncbi.nlm.nih.gov/pubmed/35719960
http://dx.doi.org/10.3389/fonc.2022.862427

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