SNPs, short tandem repeats, and structural variants are responsible for differential gene expression across C57BL/6 and C57BL/10 substrains

Mouse substrains are an invaluable model for understanding disease. We compared C57BL/6J, which is the most commonly used inbred mouse strain, with eight C57BL/6 and five C57BL/10 closely related inbred substrains. Whole-genome sequencing and RNA-sequencing analysis yielded 352,631 SNPs, 109,096 ind...

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Detalles Bibliográficos
Autores principales: Mortazavi, Milad, Ren, Yangsu, Saini, Shubham, Antaki, Danny, St. Pierre, Celine L., Williams, April, Sohni, Abhishek, Wilkinson, Miles F., Gymrek, Melissa, Sebat, Jonathan, Palmer, Abraham A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205302/
https://www.ncbi.nlm.nih.gov/pubmed/35720252
http://dx.doi.org/10.1016/j.xgen.2022.100102

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