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Design, Synthesis, and Antileukemic Evaluation of a Novel Mikanolide Derivative Through the Ras/Raf/MEK/ERK Pathway

Chronic myeloid leukemia (CML) accounts for a major cause of death in adult leukemia patients due to mutations or other reasons for dysfunction in the ABL proto-oncogene. The ubiquitous BCR–ABL expression stimulates CML by activating CDK1 and cyclin B1, promoting pro-apoptotic, and inhibiting antiap...

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Detalles Bibliográficos
Autores principales:	Rao, Qing, Xie, Kaiqiang, Varier, Krishnapriya M., Huang, Lei, Song, Jingrui, Yang, Jue, Qiu, Jianfei, Huang, Yubing, Li, Yan, Gajendran, Babu, Li, Yanmei, Liu, Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205396/ https://www.ncbi.nlm.nih.gov/pubmed/35721186 http://dx.doi.org/10.3389/fphar.2022.809551

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