Cargando…

Left Frontotemporal Region Plays a Key Role in Letter Fluency Task-Evoked Activation and Functional Connectivity in Normal Subjects: A Functional Near-Infrared Spectroscopy Study

Letter fluency task (LFT) is a tool that measures memory, executive function, and language function but lacks a definite cutoff value to define abnormalities. We used the optical signals of functional near-infrared spectroscopy (fNIRS) to study the differences in power and connectivity between the h...

Descripción completa

Detalles Bibliográficos
Autores principales: Tung, Hsin, Lin, Wei-Hao, Hsieh, Peiyuan F., Lan, Tsuo-Hung, Chiang, Ming-Chang, Lin, Yung-Yang, Peng, Syu-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205401/
https://www.ncbi.nlm.nih.gov/pubmed/35722586
http://dx.doi.org/10.3389/fpsyt.2022.810685
_version_ 1784729122174402560
author Tung, Hsin
Lin, Wei-Hao
Hsieh, Peiyuan F.
Lan, Tsuo-Hung
Chiang, Ming-Chang
Lin, Yung-Yang
Peng, Syu-Jyun
author_facet Tung, Hsin
Lin, Wei-Hao
Hsieh, Peiyuan F.
Lan, Tsuo-Hung
Chiang, Ming-Chang
Lin, Yung-Yang
Peng, Syu-Jyun
author_sort Tung, Hsin
collection PubMed
description Letter fluency task (LFT) is a tool that measures memory, executive function, and language function but lacks a definite cutoff value to define abnormalities. We used the optical signals of functional near-infrared spectroscopy (fNIRS) to study the differences in power and connectivity between the high-functioning and low-functioning participants while performing three successive LFTs, as well as the relationships between the brain network/power and LFT performance. We found that the most differentiating factor between these two groups was network topology rather than activation power. The high-functional group (7 men and 10 women) displayed higher left intra-hemispheric global efficiency, nodal strength, and shorter characteristic path length in the first section. They then demonstrated a higher power over the left Broca's area than the right corresponding area in the latter two sections. The low-LFT group (9 men and 11 women) displayed less left-lateralized connectivity and activation power. LFT performance was only related to the network topology rather than the power values, which was only presented in the low-functioning group in the second section. The direct correlation between power and connectivity primarily existed in the inter-hemispheric network, with the timing relationship also seeming to be present. In conclusion, the high-functioning group presented more prominent left-lateralized intra-hemispheric network connectivity and power activation, particularly in the Broca's area. The low-functioning group seemed to prefer using other networks, like the inter-hemispheric, rather than having a single focus on left intra-hemispheric connectivity. The network topology seemed to better reflect the LFT performance than did the power values.
format Online
Article
Text
id pubmed-9205401
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-92054012022-06-18 Left Frontotemporal Region Plays a Key Role in Letter Fluency Task-Evoked Activation and Functional Connectivity in Normal Subjects: A Functional Near-Infrared Spectroscopy Study Tung, Hsin Lin, Wei-Hao Hsieh, Peiyuan F. Lan, Tsuo-Hung Chiang, Ming-Chang Lin, Yung-Yang Peng, Syu-Jyun Front Psychiatry Psychiatry Letter fluency task (LFT) is a tool that measures memory, executive function, and language function but lacks a definite cutoff value to define abnormalities. We used the optical signals of functional near-infrared spectroscopy (fNIRS) to study the differences in power and connectivity between the high-functioning and low-functioning participants while performing three successive LFTs, as well as the relationships between the brain network/power and LFT performance. We found that the most differentiating factor between these two groups was network topology rather than activation power. The high-functional group (7 men and 10 women) displayed higher left intra-hemispheric global efficiency, nodal strength, and shorter characteristic path length in the first section. They then demonstrated a higher power over the left Broca's area than the right corresponding area in the latter two sections. The low-LFT group (9 men and 11 women) displayed less left-lateralized connectivity and activation power. LFT performance was only related to the network topology rather than the power values, which was only presented in the low-functioning group in the second section. The direct correlation between power and connectivity primarily existed in the inter-hemispheric network, with the timing relationship also seeming to be present. In conclusion, the high-functioning group presented more prominent left-lateralized intra-hemispheric network connectivity and power activation, particularly in the Broca's area. The low-functioning group seemed to prefer using other networks, like the inter-hemispheric, rather than having a single focus on left intra-hemispheric connectivity. The network topology seemed to better reflect the LFT performance than did the power values. Frontiers Media S.A. 2022-05-20 /pmc/articles/PMC9205401/ /pubmed/35722586 http://dx.doi.org/10.3389/fpsyt.2022.810685 Text en Copyright © 2022 Tung, Lin, Hsieh, Lan, Chiang, Lin and Peng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Tung, Hsin
Lin, Wei-Hao
Hsieh, Peiyuan F.
Lan, Tsuo-Hung
Chiang, Ming-Chang
Lin, Yung-Yang
Peng, Syu-Jyun
Left Frontotemporal Region Plays a Key Role in Letter Fluency Task-Evoked Activation and Functional Connectivity in Normal Subjects: A Functional Near-Infrared Spectroscopy Study
title Left Frontotemporal Region Plays a Key Role in Letter Fluency Task-Evoked Activation and Functional Connectivity in Normal Subjects: A Functional Near-Infrared Spectroscopy Study
title_full Left Frontotemporal Region Plays a Key Role in Letter Fluency Task-Evoked Activation and Functional Connectivity in Normal Subjects: A Functional Near-Infrared Spectroscopy Study
title_fullStr Left Frontotemporal Region Plays a Key Role in Letter Fluency Task-Evoked Activation and Functional Connectivity in Normal Subjects: A Functional Near-Infrared Spectroscopy Study
title_full_unstemmed Left Frontotemporal Region Plays a Key Role in Letter Fluency Task-Evoked Activation and Functional Connectivity in Normal Subjects: A Functional Near-Infrared Spectroscopy Study
title_short Left Frontotemporal Region Plays a Key Role in Letter Fluency Task-Evoked Activation and Functional Connectivity in Normal Subjects: A Functional Near-Infrared Spectroscopy Study
title_sort left frontotemporal region plays a key role in letter fluency task-evoked activation and functional connectivity in normal subjects: a functional near-infrared spectroscopy study
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205401/
https://www.ncbi.nlm.nih.gov/pubmed/35722586
http://dx.doi.org/10.3389/fpsyt.2022.810685
work_keys_str_mv AT tunghsin leftfrontotemporalregionplaysakeyroleinletterfluencytaskevokedactivationandfunctionalconnectivityinnormalsubjectsafunctionalnearinfraredspectroscopystudy
AT linweihao leftfrontotemporalregionplaysakeyroleinletterfluencytaskevokedactivationandfunctionalconnectivityinnormalsubjectsafunctionalnearinfraredspectroscopystudy
AT hsiehpeiyuanf leftfrontotemporalregionplaysakeyroleinletterfluencytaskevokedactivationandfunctionalconnectivityinnormalsubjectsafunctionalnearinfraredspectroscopystudy
AT lantsuohung leftfrontotemporalregionplaysakeyroleinletterfluencytaskevokedactivationandfunctionalconnectivityinnormalsubjectsafunctionalnearinfraredspectroscopystudy
AT chiangmingchang leftfrontotemporalregionplaysakeyroleinletterfluencytaskevokedactivationandfunctionalconnectivityinnormalsubjectsafunctionalnearinfraredspectroscopystudy
AT linyungyang leftfrontotemporalregionplaysakeyroleinletterfluencytaskevokedactivationandfunctionalconnectivityinnormalsubjectsafunctionalnearinfraredspectroscopystudy
AT pengsyujyun leftfrontotemporalregionplaysakeyroleinletterfluencytaskevokedactivationandfunctionalconnectivityinnormalsubjectsafunctionalnearinfraredspectroscopystudy