DDX41 is required for cGAS-STING activation against DNA virus infection

Upon binding double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) is activated and initiates the cGAS-stimulator of IFN genes (STING)-type I interferon pathway. DEAD-box helicase 41 (DDX41) is a DEAD-box helicase, and mutations in DDX41 cause myelodysplastic syndromes (MDSs) and acute myeloid...

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Detalles Bibliográficos
Autores principales: Singh, Ravi Shankar, Vidhyasagar, Venkatasubramanian, Yang, Shizhuo, Arna, Ananna Bhadra, Yadav, Manisha, Aggarwal, Aanchal, Aguilera, Alexya N., Shinriki, Satoru, Bhanumathy, Kalpana Kalyanasundaram, Pandey, Kannupriya, Xu, Aizhang, Rapin, Noreen, Bosch, Mark, DeCoteau, John, Xiang, Jim, Vizeacoumar, Franco J., Zhou, Yan, Misra, Vikram, Matsui, Hirotaka, Ross, Susan R., Wu, Yuliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205463/
https://www.ncbi.nlm.nih.gov/pubmed/35613581
http://dx.doi.org/10.1016/j.celrep.2022.110856

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