Network assisted analysis of de novo variants using protein-protein interaction information identified 46 candidate genes for congenital heart disease

De novo variants (DNVs) with deleterious effects have proved informative in identifying risk genes for early-onset diseases such as congenital heart disease (CHD). A number of statistical methods have been proposed for family-based studies or case/control studies to identify risk genes by screening...

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Detalles Bibliográficos
Autores principales: Xie, Yuhan, Jiang, Wei, Dong, Weilai, Li, Hongyu, Jin, Sheng Chih, Brueckner, Martina, Zhao, Hongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205499/
https://www.ncbi.nlm.nih.gov/pubmed/35671298
http://dx.doi.org/10.1371/journal.pgen.1010252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205499/
https://www.ncbi.nlm.nih.gov/pubmed/35671298
http://dx.doi.org/10.1371/journal.pgen.1010252

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