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Network assisted analysis of de novo variants using protein-protein interaction information identified 46 candidate genes for congenital heart disease
De novo variants (DNVs) with deleterious effects have proved informative in identifying risk genes for early-onset diseases such as congenital heart disease (CHD). A number of statistical methods have been proposed for family-based studies or case/control studies to identify risk genes by screening...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205499/ https://www.ncbi.nlm.nih.gov/pubmed/35671298 http://dx.doi.org/10.1371/journal.pgen.1010252 |