BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1

BACE-1 is required for generating β-amyloid (Aβ) peptides in Alzheimer’s disease (AD). Here, we report that microglial BACE-1 regulates the transition of homeostatic to stage 1 disease-associated microglia (DAM-1) signature. BACE-1 deficiency elevated levels of transcription factors including Jun, J...

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Detalles Bibliográficos
Autores principales: Singh, Neeraj, Benoit, Marc R., Zhou, John, Das, Brati, Davila-Velderrain, Jose, Kellis, Manolis, Tsai, Li-Huei, Hu, Xiangyou, Yan, Riqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205595/
https://www.ncbi.nlm.nih.gov/pubmed/35714196
http://dx.doi.org/10.1126/sciadv.abo1286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205595/
https://www.ncbi.nlm.nih.gov/pubmed/35714196
http://dx.doi.org/10.1126/sciadv.abo1286

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