Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes

Developmental gene expression is often controlled by distal regulatory DNA elements called enhancers. Distant enhancer action is restricted to structural chromosomal domains that are flanked by CTCF-associated boundaries and formed through cohesin chromatin loop extrusion. To better understand how e...

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Detalles Bibliográficos
Autores principales: Rinzema, Niels J., Sofiadis, Konstantinos, Tjalsma, Sjoerd J. D., Verstegen, Marjon J. A. M., Oz, Yuva, Valdes-Quezada, Christian, Felder, Anna-Karina, Filipovska, Teodora, van der Elst, Stefan, de Andrade dos Ramos, Zaria, Han, Ruiqi, Krijger, Peter H. L., de Laat, Wouter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205769/
https://www.ncbi.nlm.nih.gov/pubmed/35710842
http://dx.doi.org/10.1038/s41594-022-00787-7

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