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Statinintoleranz und statinassoziierte Muskelschmerzen
Statins are among the best studied drugs. Due to the extensive evidence regarding efficacy and safety, they are the cornerstone of lipid-lowering therapy. While the tolerability of statins in large blinded studies is at the placebo level, so-called statin intolerance (SI) is a frequent and complex p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Medizin
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205796/ https://www.ncbi.nlm.nih.gov/pubmed/35451596 http://dx.doi.org/10.1007/s00059-022-05114-w |
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author | Stürzebecher, Paulina Elena Schumann, Friederike Kassner, Ursula Laufs, Ulrich |
author_facet | Stürzebecher, Paulina Elena Schumann, Friederike Kassner, Ursula Laufs, Ulrich |
author_sort | Stürzebecher, Paulina Elena |
collection | PubMed |
description | Statins are among the best studied drugs. Due to the extensive evidence regarding efficacy and safety, they are the cornerstone of lipid-lowering therapy. While the tolerability of statins in large blinded studies is at the placebo level, so-called statin intolerance (SI) is a frequent and complex problem in everyday clinical practice. Statin-associated muscular pain (SAMS) is most commonly reported. In many cases SI is associated with inadequate lowering of low-density lipoprotein (LDL) cholesterol (LDL-C), thereby increasing the cardiovascular risk. The diagnosis of SAMS is based on the exclusion of possible alternative causes of muscular symptoms and the exclusion of nocebo effects through a diagnostic strategy of discontinuation of statin treatment, observation and assessment of symptoms, followed by renewed administration of a different statin initially at a low dose with subsequent dose increase. A large proportion of patients with SI and SAMS can take statins permanently and without discomfort by this approach. If LDL‑C lowering is insufficient, combination therapies are used. It is an important task of the prescribing physicians and all those involved in the treatment to increase the adherence to statins through appropriate communication. Numerous questions on SI remain open and are being addressed by an ongoing register. |
format | Online Article Text |
id | pubmed-9205796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Medizin |
record_format | MEDLINE/PubMed |
spelling | pubmed-92057962022-06-19 Statinintoleranz und statinassoziierte Muskelschmerzen Stürzebecher, Paulina Elena Schumann, Friederike Kassner, Ursula Laufs, Ulrich Herz Schwerpunkt Statins are among the best studied drugs. Due to the extensive evidence regarding efficacy and safety, they are the cornerstone of lipid-lowering therapy. While the tolerability of statins in large blinded studies is at the placebo level, so-called statin intolerance (SI) is a frequent and complex problem in everyday clinical practice. Statin-associated muscular pain (SAMS) is most commonly reported. In many cases SI is associated with inadequate lowering of low-density lipoprotein (LDL) cholesterol (LDL-C), thereby increasing the cardiovascular risk. The diagnosis of SAMS is based on the exclusion of possible alternative causes of muscular symptoms and the exclusion of nocebo effects through a diagnostic strategy of discontinuation of statin treatment, observation and assessment of symptoms, followed by renewed administration of a different statin initially at a low dose with subsequent dose increase. A large proportion of patients with SI and SAMS can take statins permanently and without discomfort by this approach. If LDL‑C lowering is insufficient, combination therapies are used. It is an important task of the prescribing physicians and all those involved in the treatment to increase the adherence to statins through appropriate communication. Numerous questions on SI remain open and are being addressed by an ongoing register. Springer Medizin 2022-04-22 2022 /pmc/articles/PMC9205796/ /pubmed/35451596 http://dx.doi.org/10.1007/s00059-022-05114-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access Dieser Artikel wird unter der Creative Commons Namensnennung 4.0 International Lizenz veröffentlicht, welche die Nutzung, Vervielfältigung, Bearbeitung, Verbreitung und Wiedergabe in jeglichem Medium und Format erlaubt, sofern Sie den/die ursprünglichen Autor(en) und die Quelle ordnungsgemäß nennen, einen Link zur Creative Commons Lizenz beifügen und angeben, ob Änderungen vorgenommen wurden. Die in diesem Artikel enthaltenen Bilder und sonstiges Drittmaterial unterliegen ebenfalls der genannten Creative Commons Lizenz, sofern sich aus der Abbildungslegende nichts anderes ergibt. Sofern das betreffende Material nicht unter der genannten Creative Commons Lizenz steht und die betreffende Handlung nicht nach gesetzlichen Vorschriften erlaubt ist, ist für die oben aufgeführten Weiterverwendungen des Materials die Einwilligung des jeweiligen Rechteinhabers einzuholen. Weitere Details zur Lizenz entnehmen Sie bitte der Lizenzinformation auf http://creativecommons.org/licenses/by/4.0/deed.de (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Schwerpunkt Stürzebecher, Paulina Elena Schumann, Friederike Kassner, Ursula Laufs, Ulrich Statinintoleranz und statinassoziierte Muskelschmerzen |
title | Statinintoleranz und statinassoziierte Muskelschmerzen |
title_full | Statinintoleranz und statinassoziierte Muskelschmerzen |
title_fullStr | Statinintoleranz und statinassoziierte Muskelschmerzen |
title_full_unstemmed | Statinintoleranz und statinassoziierte Muskelschmerzen |
title_short | Statinintoleranz und statinassoziierte Muskelschmerzen |
title_sort | statinintoleranz und statinassoziierte muskelschmerzen |
topic | Schwerpunkt |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205796/ https://www.ncbi.nlm.nih.gov/pubmed/35451596 http://dx.doi.org/10.1007/s00059-022-05114-w |
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