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Management of Pharmacologic Adverse Effects in Advanced Liver Disease

As a consequence of the altered hepatic architecture in advanced liver disease, drug metabolism is modified by changes in pharmacokinetic and pharmacodynamic properties, leading to the appearance of adverse effects and drug interactions and increasing the risk of over- or underdosing of medications....

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Autores principales: García-Cortés, Miren, García-García, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205818/
https://www.ncbi.nlm.nih.gov/pubmed/35522395
http://dx.doi.org/10.1007/s40261-022-01150-w
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author García-Cortés, Miren
García-García, Alberto
author_facet García-Cortés, Miren
García-García, Alberto
author_sort García-Cortés, Miren
collection PubMed
description As a consequence of the altered hepatic architecture in advanced liver disease, drug metabolism is modified by changes in pharmacokinetic and pharmacodynamic properties, leading to the appearance of adverse effects and drug interactions and increasing the risk of over- or underdosing of medications. However, there are no tests that accurately determine the degree of impairment of liver metabolic function; therefore, general recommendations are established based on the degree of hepatic extraction, degree of hepatic metabolism, and degree of protein binding. Although the hepatic toxicity of some frequently used drugs, such as acetaminophen, is well known, many health care professionals are unaware or not fully aware of the deleterious effects that other drugs can have on patients with advanced liver injury, as is the case for nonsteroidal anti-inflammatory drugs. It is very important to increase awareness among both health care professionals and patients with advanced liver disease to limit the use of inappropriate drugs and prevent drug-induced liver injury.
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spelling pubmed-92058182022-06-19 Management of Pharmacologic Adverse Effects in Advanced Liver Disease García-Cortés, Miren García-García, Alberto Clin Drug Investig Review Article As a consequence of the altered hepatic architecture in advanced liver disease, drug metabolism is modified by changes in pharmacokinetic and pharmacodynamic properties, leading to the appearance of adverse effects and drug interactions and increasing the risk of over- or underdosing of medications. However, there are no tests that accurately determine the degree of impairment of liver metabolic function; therefore, general recommendations are established based on the degree of hepatic extraction, degree of hepatic metabolism, and degree of protein binding. Although the hepatic toxicity of some frequently used drugs, such as acetaminophen, is well known, many health care professionals are unaware or not fully aware of the deleterious effects that other drugs can have on patients with advanced liver injury, as is the case for nonsteroidal anti-inflammatory drugs. It is very important to increase awareness among both health care professionals and patients with advanced liver disease to limit the use of inappropriate drugs and prevent drug-induced liver injury. Springer International Publishing 2022-05-06 2022 /pmc/articles/PMC9205818/ /pubmed/35522395 http://dx.doi.org/10.1007/s40261-022-01150-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review Article
García-Cortés, Miren
García-García, Alberto
Management of Pharmacologic Adverse Effects in Advanced Liver Disease
title Management of Pharmacologic Adverse Effects in Advanced Liver Disease
title_full Management of Pharmacologic Adverse Effects in Advanced Liver Disease
title_fullStr Management of Pharmacologic Adverse Effects in Advanced Liver Disease
title_full_unstemmed Management of Pharmacologic Adverse Effects in Advanced Liver Disease
title_short Management of Pharmacologic Adverse Effects in Advanced Liver Disease
title_sort management of pharmacologic adverse effects in advanced liver disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205818/
https://www.ncbi.nlm.nih.gov/pubmed/35522395
http://dx.doi.org/10.1007/s40261-022-01150-w
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