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Efficient discrimination against RNA-containing primers by human DNA polymerase ε

DNA polymerase ε (Polε) performs bulk synthesis of DNA on the leading strand during genome replication. Polε binds two substrates, a template:primer and dNTP, and catalyzes a covalent attachment of dNMP to the 3' end of the primer. Previous studies have shown that Polε easily inserts and extend...

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Detalles Bibliográficos
Autores principales:	Lisova, Alisa E., Baranovskiy, Andrey G., Morstadt, Lucia M., Babayeva, Nigar D., Tahirov, Tahir H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205888/ https://www.ncbi.nlm.nih.gov/pubmed/35715491 http://dx.doi.org/10.1038/s41598-022-14602-2

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