Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

Endocannabinoid (eCB), 2-arachidonoyl-glycerol (2-AG), the most abundant eCB in the brain, regulates diverse neural functions. Here we linked multiple homozygous loss-of-function mutations in 2-AG synthase diacylglycerol lipase β (DAGLB) to an early onset autosomal recessive Parkinsonism. DAGLB is t...

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Autores principales: Liu, Zhenhua, Yang, Nannan, Dong, Jie, Tian, Wotu, Chang, Lisa, Ma, Jinghong, Guo, Jifeng, Tan, Jieqiong, Dong, Ao, He, Kaikai, Zhou, Jingheng, Cinar, Resat, Wu, Junbing, Salinas, Armando G., Sun, Lixin, Kumar, Mantosh, Sullivan, Breanna T., Oldham, Braden B., Pitz, Vanessa, Makarious, Mary B., Ding, Jinhui, Kung, Justin, Xie, Chengsong, Hawes, Sarah L., Wang, Lupeng, Wang, Tao, Chan, Piu, Zhang, Zhuohua, Le, Weidong, Chen, Shengdi, Lovinger, David M., Blauwendraat, Cornelis, Singleton, Andrew B., Cui, Guohong, Li, Yulong, Cai, Huaibin, Tang, Beisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205912/
https://www.ncbi.nlm.nih.gov/pubmed/35715418
http://dx.doi.org/10.1038/s41467-022-31168-9

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