ZFP281-BRCA2 prevents R-loop accumulation during DNA replication

R-loops are prevalent in mammalian genomes and involved in many fundamental cellular processes. Depletion of BRCA2 leads to aberrant R-loop accumulation, contributing to genome instability. Here, we show that ZFP281 cooperates with BRCA2 in preventing R-loop accumulation to facilitate DNA replicatio...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Ma, Binbin, Liu, Xiaoxu, Gao, Ge, Che, Zhuanzhuan, Fan, Menghan, Meng, Siyan, Zhao, Xiru, Sugimura, Rio, Cao, Hua, Zhou, Zhongjun, Xie, Jing, Lin, Chengqi, Luo, Zhuojuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9205938/
https://www.ncbi.nlm.nih.gov/pubmed/35715464
http://dx.doi.org/10.1038/s41467-022-31211-9

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