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Single-cell characterization of step-wise acquisition of carboplatin resistance in ovarian cancer

The molecular underpinnings of acquired resistance to carboplatin are poorly understood and often inconsistent between in vitro modeling studies. After sequential treatment cycles, multiple isogenic clones reached similar levels of resistance, but significant transcriptional heterogeneity. Gene-expr...

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Detalles Bibliográficos
Autores principales:	Wenzel, Alexander T., Champa, Devora, Venkatesh, Hrishi, Sun, Si, Tsai, Cheng-Yu, Mesirov, Jill P., Bui, Jack D., Howell, Stephen B., Harismendy, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206019/ https://www.ncbi.nlm.nih.gov/pubmed/35715421 http://dx.doi.org/10.1038/s41540-022-00230-z

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