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The Zebrafish model in dermatology: an update for clinicians

Recently, the zebrafish has been established as one of the most important model organisms for medical research. Several studies have proved that there is a high level of similarity between human and zebrafish genomes, which encourages the use of zebrafish as a model for understanding human genetic d...

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Autores principales: Russo, Irene, Sartor, Emma, Fagotto, Laura, Colombo, Anna, Tiso, Natascia, Alaibac, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206045/
https://www.ncbi.nlm.nih.gov/pubmed/35713744
http://dx.doi.org/10.1007/s12672-022-00511-3
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author Russo, Irene
Sartor, Emma
Fagotto, Laura
Colombo, Anna
Tiso, Natascia
Alaibac, Mauro
author_facet Russo, Irene
Sartor, Emma
Fagotto, Laura
Colombo, Anna
Tiso, Natascia
Alaibac, Mauro
author_sort Russo, Irene
collection PubMed
description Recently, the zebrafish has been established as one of the most important model organisms for medical research. Several studies have proved that there is a high level of similarity between human and zebrafish genomes, which encourages the use of zebrafish as a model for understanding human genetic disorders, including cancer. Interestingly, zebrafish skin shows several similarities to human skin, suggesting that this model organism is particularly suitable for the study of neoplastic and inflammatory skin disorders. This paper appraises the specific characteristics of zebrafish skin and describes the major applications of the zebrafish model in dermatological research.
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spelling pubmed-92060452022-06-19 The Zebrafish model in dermatology: an update for clinicians Russo, Irene Sartor, Emma Fagotto, Laura Colombo, Anna Tiso, Natascia Alaibac, Mauro Discov Oncol Review Recently, the zebrafish has been established as one of the most important model organisms for medical research. Several studies have proved that there is a high level of similarity between human and zebrafish genomes, which encourages the use of zebrafish as a model for understanding human genetic disorders, including cancer. Interestingly, zebrafish skin shows several similarities to human skin, suggesting that this model organism is particularly suitable for the study of neoplastic and inflammatory skin disorders. This paper appraises the specific characteristics of zebrafish skin and describes the major applications of the zebrafish model in dermatological research. Springer US 2022-06-17 /pmc/articles/PMC9206045/ /pubmed/35713744 http://dx.doi.org/10.1007/s12672-022-00511-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Russo, Irene
Sartor, Emma
Fagotto, Laura
Colombo, Anna
Tiso, Natascia
Alaibac, Mauro
The Zebrafish model in dermatology: an update for clinicians
title The Zebrafish model in dermatology: an update for clinicians
title_full The Zebrafish model in dermatology: an update for clinicians
title_fullStr The Zebrafish model in dermatology: an update for clinicians
title_full_unstemmed The Zebrafish model in dermatology: an update for clinicians
title_short The Zebrafish model in dermatology: an update for clinicians
title_sort zebrafish model in dermatology: an update for clinicians
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206045/
https://www.ncbi.nlm.nih.gov/pubmed/35713744
http://dx.doi.org/10.1007/s12672-022-00511-3
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