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The Zebrafish model in dermatology: an update for clinicians
Recently, the zebrafish has been established as one of the most important model organisms for medical research. Several studies have proved that there is a high level of similarity between human and zebrafish genomes, which encourages the use of zebrafish as a model for understanding human genetic d...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206045/ https://www.ncbi.nlm.nih.gov/pubmed/35713744 http://dx.doi.org/10.1007/s12672-022-00511-3 |
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author | Russo, Irene Sartor, Emma Fagotto, Laura Colombo, Anna Tiso, Natascia Alaibac, Mauro |
author_facet | Russo, Irene Sartor, Emma Fagotto, Laura Colombo, Anna Tiso, Natascia Alaibac, Mauro |
author_sort | Russo, Irene |
collection | PubMed |
description | Recently, the zebrafish has been established as one of the most important model organisms for medical research. Several studies have proved that there is a high level of similarity between human and zebrafish genomes, which encourages the use of zebrafish as a model for understanding human genetic disorders, including cancer. Interestingly, zebrafish skin shows several similarities to human skin, suggesting that this model organism is particularly suitable for the study of neoplastic and inflammatory skin disorders. This paper appraises the specific characteristics of zebrafish skin and describes the major applications of the zebrafish model in dermatological research. |
format | Online Article Text |
id | pubmed-9206045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-92060452022-06-19 The Zebrafish model in dermatology: an update for clinicians Russo, Irene Sartor, Emma Fagotto, Laura Colombo, Anna Tiso, Natascia Alaibac, Mauro Discov Oncol Review Recently, the zebrafish has been established as one of the most important model organisms for medical research. Several studies have proved that there is a high level of similarity between human and zebrafish genomes, which encourages the use of zebrafish as a model for understanding human genetic disorders, including cancer. Interestingly, zebrafish skin shows several similarities to human skin, suggesting that this model organism is particularly suitable for the study of neoplastic and inflammatory skin disorders. This paper appraises the specific characteristics of zebrafish skin and describes the major applications of the zebrafish model in dermatological research. Springer US 2022-06-17 /pmc/articles/PMC9206045/ /pubmed/35713744 http://dx.doi.org/10.1007/s12672-022-00511-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Russo, Irene Sartor, Emma Fagotto, Laura Colombo, Anna Tiso, Natascia Alaibac, Mauro The Zebrafish model in dermatology: an update for clinicians |
title | The Zebrafish model in dermatology: an update for clinicians |
title_full | The Zebrafish model in dermatology: an update for clinicians |
title_fullStr | The Zebrafish model in dermatology: an update for clinicians |
title_full_unstemmed | The Zebrafish model in dermatology: an update for clinicians |
title_short | The Zebrafish model in dermatology: an update for clinicians |
title_sort | zebrafish model in dermatology: an update for clinicians |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206045/ https://www.ncbi.nlm.nih.gov/pubmed/35713744 http://dx.doi.org/10.1007/s12672-022-00511-3 |
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