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Signaling Mechanism for Modulation by GLP-1 and Exendin-4 of GABA Receptors on Rat Retinal Ganglion Cells

Glucagon-like peptide-1 (GLP-1) is expressed in retinal neurons, but its role in the retina is largely unknown. Here, we demonstrated that GLP-1 or the GLP-1 receptor (GLP-1R; a G protein-coupled receptor) agonist exendin-4 suppressed γ-aminobutyric acid receptor (GABAR)-mediated currents through GL...

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Detalles Bibliográficos
Autores principales: Zhang, Tao, Ruan, Hang-Ze, Wang, Yong-Chen, Shao, Yu-Qi, Zhou, Wei, Weng, Shi-Jun, Zhong, Yong-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206055/
https://www.ncbi.nlm.nih.gov/pubmed/35278196
http://dx.doi.org/10.1007/s12264-022-00826-9