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The immunosuppressive role of indoleamine 2, 3-dioxygenase in glioblastoma: mechanism of action and immunotherapeutic strategies

Glioblastoma multiforme (GBM) is a fatal brain tumor in adults with a bleak diagnosis. Expansion of immunosuppressive and malignant CD4 + FoxP3 + GITR + regulatory T cells is one of the hallmarks of GBM. Importantly, most of the patients with GBM expresses the tryptophan-degrading enzyme indoleamine...

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Detalles Bibliográficos
Autores principales:	Hosseinalizadeh, Hamed, Mahmoodpour, Mehrdad, Samadani, Ali Akbar, Roudkenar, Mehryar Habibi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2022
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206138/ https://www.ncbi.nlm.nih.gov/pubmed/35716323 http://dx.doi.org/10.1007/s12032-022-01724-w

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