Restoration of Cullin3 gene expression enhances the improved effects of sonic hedgehog signaling activation for hypertension and attenuates the dysfunction of vascular smooth muscle cells

BACKGROUND: Hypertension is known as a major factor for global mortality. We aimed to investigate the role of Cullin3 (CUL3) in the regulation of hypertension. MATERIAL AND METHODS: Human vascular smooth muscle cells (VSMCs) were treated with Angiotensin II (Ang II) to establish a hypertension in vi...

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Detalles Bibliográficos
Autores principales: Shen, Jian, Li, Youqi, Li, Menghao, Li, Zhiming, Deng, Huantang, Xie, Xiongwei, Liu, Jinguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206298/
https://www.ncbi.nlm.nih.gov/pubmed/35715796
http://dx.doi.org/10.1186/s12938-022-01002-w

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