Hypoalbuminemia predicts inferior outcome in patients with AIDS-related lymphoma

BACKGROUND: The prognostic value of serum albumin in acquired immunodeficiency syndrome (AIDS)-related lymphoma (ARL) remains covered. METHODS: We retrospectively analyzed de novo ARL patients from 2013 to 2019 across three centers. Factors correlated with progression-free survival (PFS) and overall...

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Autores principales: Zhang, Jinxin, Xie, Zhiman, Cai, Shaohang, Qin, Shanfang, Ruan, Guangjing, Lu, Aili, Wu, Yihua, Chen, Juanjuan, Peng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206320/
https://www.ncbi.nlm.nih.gov/pubmed/35717275
http://dx.doi.org/10.1186/s13027-022-00448-w
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author Zhang, Jinxin
Xie, Zhiman
Cai, Shaohang
Qin, Shanfang
Ruan, Guangjing
Lu, Aili
Wu, Yihua
Chen, Juanjuan
Peng, Jie
author_facet Zhang, Jinxin
Xie, Zhiman
Cai, Shaohang
Qin, Shanfang
Ruan, Guangjing
Lu, Aili
Wu, Yihua
Chen, Juanjuan
Peng, Jie
author_sort Zhang, Jinxin
collection PubMed
description BACKGROUND: The prognostic value of serum albumin in acquired immunodeficiency syndrome (AIDS)-related lymphoma (ARL) remains covered. METHODS: We retrospectively analyzed de novo ARL patients from 2013 to 2019 across three centers. Factors correlated with progression-free survival (PFS) and overall survival (OS) were evaluated in Kaplan–Meier, univariate and multivariate Cox proportional hazard models. RESULTS: A total of 86 ARL patients were enrolled with a median follow-up of 34 months. In the cohort, the OS and 2-year PFS rates were 37.5% and 35.4%, respectively. In multivariate models, older age (PFS, hazard ratios [HR] = 1.035, p = 0.037; OS, HR = 1.034, p = 0.041) and hypoalbuminemia (OS, HR = 0.910, p = 0.038) predicted inferior survival. ARL patients with hypoalbuminemia showed worse OS and 2-year PFS (p = 0.028 and p = 0.01, respectively), which was associated with poor Eastern Cooperative Oncology Group performance status (ECOG PS) and higher International Prognosis Index (IPI) score. CONCLUSION: In conclusion, serum albumin at diagnosis is an independent prognostic factor for overall survival in AIDS-related lymphoma.
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spelling pubmed-92063202022-06-19 Hypoalbuminemia predicts inferior outcome in patients with AIDS-related lymphoma Zhang, Jinxin Xie, Zhiman Cai, Shaohang Qin, Shanfang Ruan, Guangjing Lu, Aili Wu, Yihua Chen, Juanjuan Peng, Jie Infect Agent Cancer Research BACKGROUND: The prognostic value of serum albumin in acquired immunodeficiency syndrome (AIDS)-related lymphoma (ARL) remains covered. METHODS: We retrospectively analyzed de novo ARL patients from 2013 to 2019 across three centers. Factors correlated with progression-free survival (PFS) and overall survival (OS) were evaluated in Kaplan–Meier, univariate and multivariate Cox proportional hazard models. RESULTS: A total of 86 ARL patients were enrolled with a median follow-up of 34 months. In the cohort, the OS and 2-year PFS rates were 37.5% and 35.4%, respectively. In multivariate models, older age (PFS, hazard ratios [HR] = 1.035, p = 0.037; OS, HR = 1.034, p = 0.041) and hypoalbuminemia (OS, HR = 0.910, p = 0.038) predicted inferior survival. ARL patients with hypoalbuminemia showed worse OS and 2-year PFS (p = 0.028 and p = 0.01, respectively), which was associated with poor Eastern Cooperative Oncology Group performance status (ECOG PS) and higher International Prognosis Index (IPI) score. CONCLUSION: In conclusion, serum albumin at diagnosis is an independent prognostic factor for overall survival in AIDS-related lymphoma. BioMed Central 2022-06-18 /pmc/articles/PMC9206320/ /pubmed/35717275 http://dx.doi.org/10.1186/s13027-022-00448-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhang, Jinxin
Xie, Zhiman
Cai, Shaohang
Qin, Shanfang
Ruan, Guangjing
Lu, Aili
Wu, Yihua
Chen, Juanjuan
Peng, Jie
Hypoalbuminemia predicts inferior outcome in patients with AIDS-related lymphoma
title Hypoalbuminemia predicts inferior outcome in patients with AIDS-related lymphoma
title_full Hypoalbuminemia predicts inferior outcome in patients with AIDS-related lymphoma
title_fullStr Hypoalbuminemia predicts inferior outcome in patients with AIDS-related lymphoma
title_full_unstemmed Hypoalbuminemia predicts inferior outcome in patients with AIDS-related lymphoma
title_short Hypoalbuminemia predicts inferior outcome in patients with AIDS-related lymphoma
title_sort hypoalbuminemia predicts inferior outcome in patients with aids-related lymphoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206320/
https://www.ncbi.nlm.nih.gov/pubmed/35717275
http://dx.doi.org/10.1186/s13027-022-00448-w
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