The effect of implants loaded with stem cells from human exfoliated deciduous teeth on early osseointegration in a canine model

BACKGROUND: This in vivo experimental study investigated the effect of stem cells from human exfoliated deciduous teeth (SHEDs) on early osteogenesis around implants. METHODS: In four healthy adult male Beagle dogs, the left mandibular received implants and SHED as the experimental group, and the ri...

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Autores principales: Cao, Xu, Wang, Caiyun, Yuan, Dingxiang, Chen, Su, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206344/
https://www.ncbi.nlm.nih.gov/pubmed/35715777
http://dx.doi.org/10.1186/s12903-022-02264-5
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author Cao, Xu
Wang, Caiyun
Yuan, Dingxiang
Chen, Su
Wang, Xin
author_facet Cao, Xu
Wang, Caiyun
Yuan, Dingxiang
Chen, Su
Wang, Xin
author_sort Cao, Xu
collection PubMed
description BACKGROUND: This in vivo experimental study investigated the effect of stem cells from human exfoliated deciduous teeth (SHEDs) on early osteogenesis around implants. METHODS: In four healthy adult male Beagle dogs, the left mandibular received implants and SHED as the experimental group, and the right mandibular received implants and phosphate-buffered saline as the control group. The Beagle dogs were randomly divided into groups A and B, which were sacrificed at 2 and 4 weeks after implantation. Micro-computed tomography and histological analysis were used to investigate the effect of SHED-loading on the early osseointegration around the implants. RESULTS: The total bone-to-implant contact (BIC%) and interthread bone improved significantly. The analysis of the bone volume fraction and trabecular thickness showed that the bone trabecula around the implants in the SHEDs group was thicker and denser than that in the control group, suggesting a better osseointegration. CONCLUSIONS: The application of implants pre-adhered with SHEDs improved and accelerated early osseointegration around the implant, resulting in thicker and denser trabecular bone.
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spelling pubmed-92063442022-06-19 The effect of implants loaded with stem cells from human exfoliated deciduous teeth on early osseointegration in a canine model Cao, Xu Wang, Caiyun Yuan, Dingxiang Chen, Su Wang, Xin BMC Oral Health Research BACKGROUND: This in vivo experimental study investigated the effect of stem cells from human exfoliated deciduous teeth (SHEDs) on early osteogenesis around implants. METHODS: In four healthy adult male Beagle dogs, the left mandibular received implants and SHED as the experimental group, and the right mandibular received implants and phosphate-buffered saline as the control group. The Beagle dogs were randomly divided into groups A and B, which were sacrificed at 2 and 4 weeks after implantation. Micro-computed tomography and histological analysis were used to investigate the effect of SHED-loading on the early osseointegration around the implants. RESULTS: The total bone-to-implant contact (BIC%) and interthread bone improved significantly. The analysis of the bone volume fraction and trabecular thickness showed that the bone trabecula around the implants in the SHEDs group was thicker and denser than that in the control group, suggesting a better osseointegration. CONCLUSIONS: The application of implants pre-adhered with SHEDs improved and accelerated early osseointegration around the implant, resulting in thicker and denser trabecular bone. BioMed Central 2022-06-17 /pmc/articles/PMC9206344/ /pubmed/35715777 http://dx.doi.org/10.1186/s12903-022-02264-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Cao, Xu
Wang, Caiyun
Yuan, Dingxiang
Chen, Su
Wang, Xin
The effect of implants loaded with stem cells from human exfoliated deciduous teeth on early osseointegration in a canine model
title The effect of implants loaded with stem cells from human exfoliated deciduous teeth on early osseointegration in a canine model
title_full The effect of implants loaded with stem cells from human exfoliated deciduous teeth on early osseointegration in a canine model
title_fullStr The effect of implants loaded with stem cells from human exfoliated deciduous teeth on early osseointegration in a canine model
title_full_unstemmed The effect of implants loaded with stem cells from human exfoliated deciduous teeth on early osseointegration in a canine model
title_short The effect of implants loaded with stem cells from human exfoliated deciduous teeth on early osseointegration in a canine model
title_sort effect of implants loaded with stem cells from human exfoliated deciduous teeth on early osseointegration in a canine model
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206344/
https://www.ncbi.nlm.nih.gov/pubmed/35715777
http://dx.doi.org/10.1186/s12903-022-02264-5
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