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LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions

BACKGROUND: Microglia plays crucial roles in Alzheimer’s disease (AD) development. Triggering receptor expressed on myeloid cells 2 (TREM2) in association with DAP12 mediates signaling affecting microglia function. Here we study the negative regulation of TREM2 functions by leukocyte immunoglobulin-...

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Detalles Bibliográficos
Autores principales:	Zhao, Peng, Xu, Yuanzhong, Jiang, Lu-Lin, Fan, Xuejun, Ku, Zhiqiang, Li, Leike, Liu, Xiaoye, Deng, Mi, Arase, Hisashi, Zhu, Jay-Jiguang, Huang, Timothy Y., Zhao, Yingjun, Zhang, Chengcheng, Xu, Huaxi, Tong, Qingchun, Zhang, Ningyan, An, Zhiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206387/ https://www.ncbi.nlm.nih.gov/pubmed/35717259 http://dx.doi.org/10.1186/s13024-022-00550-y

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