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Genistein induces long-term expression of progesterone receptor regardless of estrogen receptor status and improves the prognosis of endometrial cancer patients

Progesterone is used to treat uterine endometrial cancer in young patients wishing to preserve their fertility as well as in advanced or recurrent patients, but its response rate is limited. The antitumor effect of progesterone is mediated by progesterone receptor (PR) binding. Hence, loss of proges...

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Detalles Bibliográficos
Autores principales: Yoriki, Kaori, Mori, Taisuke, Aoyama, Kohei, Tarumi, Yosuke, Kataoka, Hisashi, Kokabu, Tetsuya, Kitawaki, Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206647/
https://www.ncbi.nlm.nih.gov/pubmed/35717540
http://dx.doi.org/10.1038/s41598-022-13842-6