Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells

Constitutive activation of cyclin-dependent kinases (CDKs) or arginine auxotrophy are hallmarks of Glioblastoma multiforme (GBM). The latter metabolic defect renders tumor cells vulnerable to arginine-depleting substances, such as arginine deiminase from Streptococcus pyogenes (SpyADI). Previously,...

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Detalles Bibliográficos
Autores principales: Riess, Christin, del Moral, Katharina, Fiebig, Adina, Kaps, Philipp, Linke, Charlotte, Hinz, Burkhard, Rupprecht, Anne, Frank, Marcus, Fiedler, Tomas, Koczan, Dirk, Troschke-Meurer, Sascha, Lode, Holger N., Engel, Nadja, Freitag, Thomas, Classen, Carl Friedrich, Maletzki, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206658/
https://www.ncbi.nlm.nih.gov/pubmed/35717443
http://dx.doi.org/10.1038/s41419-022-05006-1

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