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Complex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity

Gephyrin (GPHN) regulates the clustering of postsynaptic components at inhibitory synapses and is involved in pathophysiology of neuropsychiatric disorders. Here, we uncover an extensive diversity of GPHN transcripts that are tightly controlled by splicing during mouse and human brain development. P...

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Detalles Bibliográficos
Autores principales: Dos Reis, Raphaël, Kornobis, Etienne, Pereira, Alyssa, Tores, Frederic, Carrasco, Judit, Gautier, Candice, Jahannault-Talignani, Céline, Nitschké, Patrick, Muchardt, Christian, Schlosser, Andreas, Maric, Hans Michael, Ango, Fabrice, Allemand, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206673/
https://www.ncbi.nlm.nih.gov/pubmed/35717442
http://dx.doi.org/10.1038/s41467-022-31264-w