Cargando…

Effects of Methamphetamine Withdrawal on the Volume and pH of Stimulated Saliva

STATEMENT OF THE PROBLEM: As a stimulant drug of the central nervous system, methamphetamine reduces salivary secretion by stimulating inhibitory α2-receptors in the sympathetic system. The acidity of this substance reduces the salivary pH and causes severe dental caries and erosion in the cervical...

Descripción completa

Detalles Bibliográficos
Autores principales: Zokaee, Haleh, Fathi, Shima, Golalipour, Hossein, Mirzaei, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University of Medical Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206696/
https://www.ncbi.nlm.nih.gov/pubmed/35783497
http://dx.doi.org/10.30476/DENTJODS.2021.87248.1244
_version_ 1784729387601494016
author Zokaee, Haleh
Fathi, Shima
Golalipour, Hossein
Mirzaei, Fatemeh
author_facet Zokaee, Haleh
Fathi, Shima
Golalipour, Hossein
Mirzaei, Fatemeh
author_sort Zokaee, Haleh
collection PubMed
description STATEMENT OF THE PROBLEM: As a stimulant drug of the central nervous system, methamphetamine reduces salivary secretion by stimulating inhibitory α2-receptors in the sympathetic system. The acidity of this substance reduces the salivary pH and causes severe dental caries and erosion in the cervical region of teeth, appearing as "meth mouth". PURPOSE: This study aimed to determine the effects of methamphetamine withdrawal on the volume and pH of stimulated saliva in patients under treatment at rehabilitation centers. MATERIALS AND METHOD: This descriptive cross-sectional study was conducted on a total of 20 individuals at the rehabilitation centers of Gorgan, Iran. The volume and pH of stimulated saliva were measured at three intervals: before withdrawal, four days after withdrawal, and 30 days after withdrawal. Data analysis was performed using ANOVA test in SPSS. RESULTS: The results showed a significant difference in the mean volume of saliva before and after withdrawal (p< 0.05). Thirty days after withdrawal, the mean volume of saliva was significantly different from the mean volume after four days (p< 0.05). Moreover, the mean pH of saliva after withdrawal was significantly different from the mean pH before withdrawal (p< 0.001). On the other hand, the mean salivary pH at 30 days after withdrawal was not significantly different from the mean pH on the fourth day after withdrawal (p> 0.05). CONCLUSION: It seems that methamphetamine withdrawal influences the volume and pH of stimulated saliva in patients under treatment at rehabilitation centers.
format Online
Article
Text
id pubmed-9206696
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Shiraz University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-92066962022-07-02 Effects of Methamphetamine Withdrawal on the Volume and pH of Stimulated Saliva Zokaee, Haleh Fathi, Shima Golalipour, Hossein Mirzaei, Fatemeh J Dent (Shiraz) Original Article STATEMENT OF THE PROBLEM: As a stimulant drug of the central nervous system, methamphetamine reduces salivary secretion by stimulating inhibitory α2-receptors in the sympathetic system. The acidity of this substance reduces the salivary pH and causes severe dental caries and erosion in the cervical region of teeth, appearing as "meth mouth". PURPOSE: This study aimed to determine the effects of methamphetamine withdrawal on the volume and pH of stimulated saliva in patients under treatment at rehabilitation centers. MATERIALS AND METHOD: This descriptive cross-sectional study was conducted on a total of 20 individuals at the rehabilitation centers of Gorgan, Iran. The volume and pH of stimulated saliva were measured at three intervals: before withdrawal, four days after withdrawal, and 30 days after withdrawal. Data analysis was performed using ANOVA test in SPSS. RESULTS: The results showed a significant difference in the mean volume of saliva before and after withdrawal (p< 0.05). Thirty days after withdrawal, the mean volume of saliva was significantly different from the mean volume after four days (p< 0.05). Moreover, the mean pH of saliva after withdrawal was significantly different from the mean pH before withdrawal (p< 0.001). On the other hand, the mean salivary pH at 30 days after withdrawal was not significantly different from the mean pH on the fourth day after withdrawal (p> 0.05). CONCLUSION: It seems that methamphetamine withdrawal influences the volume and pH of stimulated saliva in patients under treatment at rehabilitation centers. Shiraz University of Medical Sciences 2022-06 /pmc/articles/PMC9206696/ /pubmed/35783497 http://dx.doi.org/10.30476/DENTJODS.2021.87248.1244 Text en Copyright: © Journal of Dentistry https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License, ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zokaee, Haleh
Fathi, Shima
Golalipour, Hossein
Mirzaei, Fatemeh
Effects of Methamphetamine Withdrawal on the Volume and pH of Stimulated Saliva
title Effects of Methamphetamine Withdrawal on the Volume and pH of Stimulated Saliva
title_full Effects of Methamphetamine Withdrawal on the Volume and pH of Stimulated Saliva
title_fullStr Effects of Methamphetamine Withdrawal on the Volume and pH of Stimulated Saliva
title_full_unstemmed Effects of Methamphetamine Withdrawal on the Volume and pH of Stimulated Saliva
title_short Effects of Methamphetamine Withdrawal on the Volume and pH of Stimulated Saliva
title_sort effects of methamphetamine withdrawal on the volume and ph of stimulated saliva
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206696/
https://www.ncbi.nlm.nih.gov/pubmed/35783497
http://dx.doi.org/10.30476/DENTJODS.2021.87248.1244
work_keys_str_mv AT zokaeehaleh effectsofmethamphetaminewithdrawalonthevolumeandphofstimulatedsaliva
AT fathishima effectsofmethamphetaminewithdrawalonthevolumeandphofstimulatedsaliva
AT golalipourhossein effectsofmethamphetaminewithdrawalonthevolumeandphofstimulatedsaliva
AT mirzaeifatemeh effectsofmethamphetaminewithdrawalonthevolumeandphofstimulatedsaliva