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Evaluation of Expanded Criteria Donors Using the Kidney Donor Profile Index and the Preimplantation Renal Biopsy

The increasing comorbidity of kidney transplant (KT) donors make it necessary to develop scores to correctly assess the quality of kidney grafts. This study analyzes the usefulness of the preimplantation biopsy and the Kidney Donor Profile Index (KDPI) as indicators of KT survival from expanded crit...

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Autores principales: Villanego, F., Vigara, L. A., Cazorla, J. M., Naranjo, J., Atienza, L., Garcia, A. M., Montero, M. E., Minguez, M. C., Garcia, T., Mazuecos, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207180/
https://www.ncbi.nlm.nih.gov/pubmed/35734238
http://dx.doi.org/10.3389/ti.2022.10056
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author Villanego, F.
Vigara, L. A.
Cazorla, J. M.
Naranjo, J.
Atienza, L.
Garcia, A. M.
Montero, M. E.
Minguez, M. C.
Garcia, T.
Mazuecos, A.
author_facet Villanego, F.
Vigara, L. A.
Cazorla, J. M.
Naranjo, J.
Atienza, L.
Garcia, A. M.
Montero, M. E.
Minguez, M. C.
Garcia, T.
Mazuecos, A.
author_sort Villanego, F.
collection PubMed
description The increasing comorbidity of kidney transplant (KT) donors make it necessary to develop scores to correctly assess the quality of kidney grafts. This study analyzes the usefulness of the preimplantation biopsy and the Kidney Donor Profile Index (KDPI) as indicators of KT survival from expanded criteria donors (ECD). Retrospective study of KT in our center between January 2010 to June 2019 who received a kidney from an ECD and underwent a preimplantation biopsy. 266 KT were included. Graft survival was categorized by KDPI quartiles: Q1 = 86%, Q2 = 95%, Q3 = 99% and Q4 = 100%. KT from KDPI Q1 presented better survival (p = 0.003) and Q4 donors had worse renal function (p = 0.018) and poorer glomerular filtration rate (3rd month; p = 0.017, 1st year; p = 0.010). KT survival was analyzed according to KDPI quartile and preimplantation biopsy score simultaneously: Q1 donors with biopsy score ≤3 had the best survival, especially comparing against Q3 with a biopsy score >3 and Q4 donors (p = 0.014). In multivariable analysis, hyaline arteriopathy, glomerulosclerosis, and KDPI Q4 were predictors for graft survival. High KDPI and a greater histological injury in the preimplantation biopsy, especially glomerular and vascular lesions, were related to a higher rate of KT loss from ECD.
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spelling pubmed-92071802022-06-21 Evaluation of Expanded Criteria Donors Using the Kidney Donor Profile Index and the Preimplantation Renal Biopsy Villanego, F. Vigara, L. A. Cazorla, J. M. Naranjo, J. Atienza, L. Garcia, A. M. Montero, M. E. Minguez, M. C. Garcia, T. Mazuecos, A. Transpl Int Health Archive The increasing comorbidity of kidney transplant (KT) donors make it necessary to develop scores to correctly assess the quality of kidney grafts. This study analyzes the usefulness of the preimplantation biopsy and the Kidney Donor Profile Index (KDPI) as indicators of KT survival from expanded criteria donors (ECD). Retrospective study of KT in our center between January 2010 to June 2019 who received a kidney from an ECD and underwent a preimplantation biopsy. 266 KT were included. Graft survival was categorized by KDPI quartiles: Q1 = 86%, Q2 = 95%, Q3 = 99% and Q4 = 100%. KT from KDPI Q1 presented better survival (p = 0.003) and Q4 donors had worse renal function (p = 0.018) and poorer glomerular filtration rate (3rd month; p = 0.017, 1st year; p = 0.010). KT survival was analyzed according to KDPI quartile and preimplantation biopsy score simultaneously: Q1 donors with biopsy score ≤3 had the best survival, especially comparing against Q3 with a biopsy score >3 and Q4 donors (p = 0.014). In multivariable analysis, hyaline arteriopathy, glomerulosclerosis, and KDPI Q4 were predictors for graft survival. High KDPI and a greater histological injury in the preimplantation biopsy, especially glomerular and vascular lesions, were related to a higher rate of KT loss from ECD. Frontiers Media S.A. 2022-06-06 /pmc/articles/PMC9207180/ /pubmed/35734238 http://dx.doi.org/10.3389/ti.2022.10056 Text en Copyright © 2022 Villanego, Vigara, Cazorla, Naranjo, Atienza, Garcia, Montero, Minguez, Garcia and Mazuecos. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Villanego, F.
Vigara, L. A.
Cazorla, J. M.
Naranjo, J.
Atienza, L.
Garcia, A. M.
Montero, M. E.
Minguez, M. C.
Garcia, T.
Mazuecos, A.
Evaluation of Expanded Criteria Donors Using the Kidney Donor Profile Index and the Preimplantation Renal Biopsy
title Evaluation of Expanded Criteria Donors Using the Kidney Donor Profile Index and the Preimplantation Renal Biopsy
title_full Evaluation of Expanded Criteria Donors Using the Kidney Donor Profile Index and the Preimplantation Renal Biopsy
title_fullStr Evaluation of Expanded Criteria Donors Using the Kidney Donor Profile Index and the Preimplantation Renal Biopsy
title_full_unstemmed Evaluation of Expanded Criteria Donors Using the Kidney Donor Profile Index and the Preimplantation Renal Biopsy
title_short Evaluation of Expanded Criteria Donors Using the Kidney Donor Profile Index and the Preimplantation Renal Biopsy
title_sort evaluation of expanded criteria donors using the kidney donor profile index and the preimplantation renal biopsy
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207180/
https://www.ncbi.nlm.nih.gov/pubmed/35734238
http://dx.doi.org/10.3389/ti.2022.10056
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