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A Novel Combined Nomogram Model for Predicting the Pathological Complete Response to Neoadjuvant Chemotherapy in Invasive Breast Carcinoma of No Specific Type: Real-World Study

OBJECTIVE: To explore the value of a predictive model combining the multiparametric magnetic resonance imaging (mpMRI) radiomics score (RAD-score), clinicopathologic features, and morphologic features for the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in invasive breast c...

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Autores principales: Zhu, Xuelin, Shen, Jing, Zhang, Huanlei, Wang, Xiulin, Zhang, Huihui, Yu, Jing, Zhang, Qing, Song, Dongdong, Guo, Liping, Zhang, Dianlong, Zhu, Ruiping, Wu, Jianlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207207/
https://www.ncbi.nlm.nih.gov/pubmed/35734603
http://dx.doi.org/10.3389/fonc.2022.916526
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author Zhu, Xuelin
Shen, Jing
Zhang, Huanlei
Wang, Xiulin
Zhang, Huihui
Yu, Jing
Zhang, Qing
Song, Dongdong
Guo, Liping
Zhang, Dianlong
Zhu, Ruiping
Wu, Jianlin
author_facet Zhu, Xuelin
Shen, Jing
Zhang, Huanlei
Wang, Xiulin
Zhang, Huihui
Yu, Jing
Zhang, Qing
Song, Dongdong
Guo, Liping
Zhang, Dianlong
Zhu, Ruiping
Wu, Jianlin
author_sort Zhu, Xuelin
collection PubMed
description OBJECTIVE: To explore the value of a predictive model combining the multiparametric magnetic resonance imaging (mpMRI) radiomics score (RAD-score), clinicopathologic features, and morphologic features for the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in invasive breast carcinoma of no specific type (IBC-NST). METHODS: We enrolled, retrospectively and consecutively, 206 women with IBC-NST who underwent surgery after NAC and obtained pathological results from August 2018 to October 2021. Four RAD-scores were constructed for predicting the pCR based on fat-suppression T2-weighted imaging (FS-T2WI), diffusion-weighted imaging (DWI), contrast-enhanced T1-weighted imaging (T1WI+C) and their combination, which was called mpMRI. The best RAD-score was combined with clinicopathologic and morphologic features to establish a nomogram model through binary logistic regression. The predictive performance of the nomogram was evaluated using the area under receiver operator characteristic (ROC) curve (AUC) and calibration curve. The clinical net benefit of the model was evaluated using decision curve analysis (DCA). RESULTS: The mpMRI RAD-score had the highest diagnostic performance, with AUC of 0.848 among the four RAD-scores. T stage, human epidermal growth factor receptor-2 (HER2) status, RAD-score, and roundness were independent factors for predicting the pCR (P < 0.05 for all). The combined nomogram model based on these factors achieved AUCs of 0.930 and 0.895 in the training cohort and validation cohort, respectively, higher than other models (P < 0.05 for all). The calibration curve showed that the predicted probabilities of the nomogram were in good agreement with the actual probabilities, and DCA indicated that it provided more net benefit than the treat-none or treat-all scheme by decision curve analysis in both training and validation datasets. CONCLUSION: The combined nomogram model based on the mpMRI RAD-score combined with clinicopathologic and morphologic features may improve the predictive performance for the pCR of NAC in patients with IBC-NST.
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spelling pubmed-92072072022-06-21 A Novel Combined Nomogram Model for Predicting the Pathological Complete Response to Neoadjuvant Chemotherapy in Invasive Breast Carcinoma of No Specific Type: Real-World Study Zhu, Xuelin Shen, Jing Zhang, Huanlei Wang, Xiulin Zhang, Huihui Yu, Jing Zhang, Qing Song, Dongdong Guo, Liping Zhang, Dianlong Zhu, Ruiping Wu, Jianlin Front Oncol Oncology OBJECTIVE: To explore the value of a predictive model combining the multiparametric magnetic resonance imaging (mpMRI) radiomics score (RAD-score), clinicopathologic features, and morphologic features for the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in invasive breast carcinoma of no specific type (IBC-NST). METHODS: We enrolled, retrospectively and consecutively, 206 women with IBC-NST who underwent surgery after NAC and obtained pathological results from August 2018 to October 2021. Four RAD-scores were constructed for predicting the pCR based on fat-suppression T2-weighted imaging (FS-T2WI), diffusion-weighted imaging (DWI), contrast-enhanced T1-weighted imaging (T1WI+C) and their combination, which was called mpMRI. The best RAD-score was combined with clinicopathologic and morphologic features to establish a nomogram model through binary logistic regression. The predictive performance of the nomogram was evaluated using the area under receiver operator characteristic (ROC) curve (AUC) and calibration curve. The clinical net benefit of the model was evaluated using decision curve analysis (DCA). RESULTS: The mpMRI RAD-score had the highest diagnostic performance, with AUC of 0.848 among the four RAD-scores. T stage, human epidermal growth factor receptor-2 (HER2) status, RAD-score, and roundness were independent factors for predicting the pCR (P < 0.05 for all). The combined nomogram model based on these factors achieved AUCs of 0.930 and 0.895 in the training cohort and validation cohort, respectively, higher than other models (P < 0.05 for all). The calibration curve showed that the predicted probabilities of the nomogram were in good agreement with the actual probabilities, and DCA indicated that it provided more net benefit than the treat-none or treat-all scheme by decision curve analysis in both training and validation datasets. CONCLUSION: The combined nomogram model based on the mpMRI RAD-score combined with clinicopathologic and morphologic features may improve the predictive performance for the pCR of NAC in patients with IBC-NST. Frontiers Media S.A. 2022-06-06 /pmc/articles/PMC9207207/ /pubmed/35734603 http://dx.doi.org/10.3389/fonc.2022.916526 Text en Copyright © 2022 Zhu, Shen, Zhang, Wang, Zhang, Yu, Zhang, Song, Guo, Zhang, Zhu and Wu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhu, Xuelin
Shen, Jing
Zhang, Huanlei
Wang, Xiulin
Zhang, Huihui
Yu, Jing
Zhang, Qing
Song, Dongdong
Guo, Liping
Zhang, Dianlong
Zhu, Ruiping
Wu, Jianlin
A Novel Combined Nomogram Model for Predicting the Pathological Complete Response to Neoadjuvant Chemotherapy in Invasive Breast Carcinoma of No Specific Type: Real-World Study
title A Novel Combined Nomogram Model for Predicting the Pathological Complete Response to Neoadjuvant Chemotherapy in Invasive Breast Carcinoma of No Specific Type: Real-World Study
title_full A Novel Combined Nomogram Model for Predicting the Pathological Complete Response to Neoadjuvant Chemotherapy in Invasive Breast Carcinoma of No Specific Type: Real-World Study
title_fullStr A Novel Combined Nomogram Model for Predicting the Pathological Complete Response to Neoadjuvant Chemotherapy in Invasive Breast Carcinoma of No Specific Type: Real-World Study
title_full_unstemmed A Novel Combined Nomogram Model for Predicting the Pathological Complete Response to Neoadjuvant Chemotherapy in Invasive Breast Carcinoma of No Specific Type: Real-World Study
title_short A Novel Combined Nomogram Model for Predicting the Pathological Complete Response to Neoadjuvant Chemotherapy in Invasive Breast Carcinoma of No Specific Type: Real-World Study
title_sort novel combined nomogram model for predicting the pathological complete response to neoadjuvant chemotherapy in invasive breast carcinoma of no specific type: real-world study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207207/
https://www.ncbi.nlm.nih.gov/pubmed/35734603
http://dx.doi.org/10.3389/fonc.2022.916526
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