An Endoplasmic Reticulum-Targeted Ratiometric Fluorescent Molecule Reveals Zn(2+) Micro-Dynamics During Drug-Induced Organelle Ionic Disorder

The endoplasmic reticulum (ER) is the main storage site of Zn(2+), and Zn(2+) plays an important role in regulating ER homeostasis. Therefore, we designed and synthesized a ratiometric fluorescent Zn(2+) probe ER-Zn targeting ER stress. The probe displayed a specific Zn(2+) induced blue shift at the...

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Detalles Bibliográficos
Autores principales: Fang, Hongbao, Li, Yaheng, Yao, Shankun, Geng, Shanshan, Chen, Yuncong, Guo, Zijian, He, Weijiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207263/
https://www.ncbi.nlm.nih.gov/pubmed/35734408
http://dx.doi.org/10.3389/fphar.2022.927609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207263/
https://www.ncbi.nlm.nih.gov/pubmed/35734408
http://dx.doi.org/10.3389/fphar.2022.927609

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