Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients

N6-methyladenosine (m6a)-related mRNAs and lncRNAs have been explored for their functions in several cancers. The present study aimed to identify potential signatures of m6a-related lncRNAs in hepatocellular carcinoma (HCC). We downloaded the expression and clinical data from The Cancer Genome Atlas...

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Autores principales: Wu, Xianbin, Deng, Zhejun, Liao, Xiaomin, Ruan, Xianxian, Qu, Nanfang, Pang, Lixing, Shi, Xiaoyan, Qin, Shanyu, Jiang, Haixing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207396/
https://www.ncbi.nlm.nih.gov/pubmed/35734590
http://dx.doi.org/10.3389/fonc.2022.865917
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author Wu, Xianbin
Deng, Zhejun
Liao, Xiaomin
Ruan, Xianxian
Qu, Nanfang
Pang, Lixing
Shi, Xiaoyan
Qin, Shanyu
Jiang, Haixing
author_facet Wu, Xianbin
Deng, Zhejun
Liao, Xiaomin
Ruan, Xianxian
Qu, Nanfang
Pang, Lixing
Shi, Xiaoyan
Qin, Shanyu
Jiang, Haixing
author_sort Wu, Xianbin
collection PubMed
description N6-methyladenosine (m6a)-related mRNAs and lncRNAs have been explored for their functions in several cancers. The present study aimed to identify potential signatures of m6a-related lncRNAs in hepatocellular carcinoma (HCC). We downloaded the expression and clinical data from The Cancer Genome Atlas (TCGA) database. The interacted mRNAs and lncRNAs, prognosis-related lncRNAs, potential metabolic pathways of lncRNAs, immune infiltration of various cells, and CD274 (PD-L1) -related lncRNAs were analyzed. Then, in vitro experiments explored the role of AC012073.1 (LOC105377626) in HCC cell lines. We found that candidate 14 lncRNA signatures play functions in HCC maybe by affecting immune infiltration, cell cycle, Notch signaling pathway, etc. LncRNA AC012073.1 (LOC105377626) functions as oncogenic roles in affecting HCC prognosis.
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spelling pubmed-92073962022-06-21 Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients Wu, Xianbin Deng, Zhejun Liao, Xiaomin Ruan, Xianxian Qu, Nanfang Pang, Lixing Shi, Xiaoyan Qin, Shanyu Jiang, Haixing Front Oncol Oncology N6-methyladenosine (m6a)-related mRNAs and lncRNAs have been explored for their functions in several cancers. The present study aimed to identify potential signatures of m6a-related lncRNAs in hepatocellular carcinoma (HCC). We downloaded the expression and clinical data from The Cancer Genome Atlas (TCGA) database. The interacted mRNAs and lncRNAs, prognosis-related lncRNAs, potential metabolic pathways of lncRNAs, immune infiltration of various cells, and CD274 (PD-L1) -related lncRNAs were analyzed. Then, in vitro experiments explored the role of AC012073.1 (LOC105377626) in HCC cell lines. We found that candidate 14 lncRNA signatures play functions in HCC maybe by affecting immune infiltration, cell cycle, Notch signaling pathway, etc. LncRNA AC012073.1 (LOC105377626) functions as oncogenic roles in affecting HCC prognosis. Frontiers Media S.A. 2022-06-06 /pmc/articles/PMC9207396/ /pubmed/35734590 http://dx.doi.org/10.3389/fonc.2022.865917 Text en Copyright © 2022 Wu, Deng, Liao, Ruan, Qu, Pang, Shi, Qin and Jiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Xianbin
Deng, Zhejun
Liao, Xiaomin
Ruan, Xianxian
Qu, Nanfang
Pang, Lixing
Shi, Xiaoyan
Qin, Shanyu
Jiang, Haixing
Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients
title Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients
title_full Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients
title_fullStr Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients
title_full_unstemmed Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients
title_short Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients
title_sort establishment of prognostic signatures of n6-methyladenosine-related lncrnas and their potential functions in hepatocellular carcinoma patients
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207396/
https://www.ncbi.nlm.nih.gov/pubmed/35734590
http://dx.doi.org/10.3389/fonc.2022.865917
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