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Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing

Acoustic change complex (ACC) is a cortical auditory-evoked potential induced by a change of continuous sound stimulation. This study aimed to explore: (1) whether the change of horizontal sound location can elicit ACC; (2) the relationship between the change of sound location and the amplitude or l...

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Autores principales: Fan, Zhi-Tong, Zhao, Zi-Hui, Sharma, Mridula, Valderrama, Joaquin T., Fu, Qian-Jie, Liu, Jia-Xing, Fu, Xin, Li, Huan, Zhao, Xue-Lei, Guo, Xin-Yu, Fu, Luo-Yi, Wang, Ning-Yu, Zhang, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207405/
https://www.ncbi.nlm.nih.gov/pubmed/35733932
http://dx.doi.org/10.3389/fnins.2022.908989
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author Fan, Zhi-Tong
Zhao, Zi-Hui
Sharma, Mridula
Valderrama, Joaquin T.
Fu, Qian-Jie
Liu, Jia-Xing
Fu, Xin
Li, Huan
Zhao, Xue-Lei
Guo, Xin-Yu
Fu, Luo-Yi
Wang, Ning-Yu
Zhang, Juan
author_facet Fan, Zhi-Tong
Zhao, Zi-Hui
Sharma, Mridula
Valderrama, Joaquin T.
Fu, Qian-Jie
Liu, Jia-Xing
Fu, Xin
Li, Huan
Zhao, Xue-Lei
Guo, Xin-Yu
Fu, Luo-Yi
Wang, Ning-Yu
Zhang, Juan
author_sort Fan, Zhi-Tong
collection PubMed
description Acoustic change complex (ACC) is a cortical auditory-evoked potential induced by a change of continuous sound stimulation. This study aimed to explore: (1) whether the change of horizontal sound location can elicit ACC; (2) the relationship between the change of sound location and the amplitude or latency of ACC; (3) the relationship between the behavioral measure of localization, minimum audible angle (MAA), and ACC. A total of 36 normal-hearing adults participated in this study. A 180° horizontal arc-shaped bracket with a 1.2 m radius was set in a sound field where participants sat at the center. MAA was measured in a two-alternative forced-choice setting. The objective electroencephalography recording of ACC was conducted with the location changed at four sets of positions, ±45°, ±15°, ±5°, and ±2°. The test stimulus was a 125–6,000 Hz broadband noise of 1 s at 60 ± 2 dB SPL with a 2 s interval. The N1′–P2′ amplitudes, N1′ latencies, and P2′ latencies of ACC under four positions were evaluated. The influence of electrode sites and the direction of sound position change on ACC waveform was analyzed with analysis of variance. Results suggested that (1) ACC can be elicited successfully by changing the horizontal sound location position. The elicitation rate of ACC increased with the increase of location change. (2) N1′–P2′ amplitude increased and N1′ and P2′ latencies decreased as the change of sound location increased. The effects of test angles on N1′–P2′ amplitude [F(1.91,238.1) = 97.172, p < 0.001], N1′ latency [F(1.78,221.90) = 96.96, p < 0.001], and P2′ latency [F(1.87,233.11) = 79.97, p < 0.001] showed a statistical significance. (3) The direction of sound location change had no significant effect on any of the ACC peak amplitudes or latencies. (4) Sound location discrimination threshold by the ACC test (97.0% elicitation rate at ±5°) was higher than MAA threshold (2.08 ± 0.5°). The current study results show that though the ACC thresholds are higher than the behavioral thresholds on MAA task, ACC can be used as an objective method to evaluate sound localization ability. This article discusses the implications of this research for clinical practice and evaluation of localization skills, especially for children.
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spelling pubmed-92074052022-06-21 Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing Fan, Zhi-Tong Zhao, Zi-Hui Sharma, Mridula Valderrama, Joaquin T. Fu, Qian-Jie Liu, Jia-Xing Fu, Xin Li, Huan Zhao, Xue-Lei Guo, Xin-Yu Fu, Luo-Yi Wang, Ning-Yu Zhang, Juan Front Neurosci Neuroscience Acoustic change complex (ACC) is a cortical auditory-evoked potential induced by a change of continuous sound stimulation. This study aimed to explore: (1) whether the change of horizontal sound location can elicit ACC; (2) the relationship between the change of sound location and the amplitude or latency of ACC; (3) the relationship between the behavioral measure of localization, minimum audible angle (MAA), and ACC. A total of 36 normal-hearing adults participated in this study. A 180° horizontal arc-shaped bracket with a 1.2 m radius was set in a sound field where participants sat at the center. MAA was measured in a two-alternative forced-choice setting. The objective electroencephalography recording of ACC was conducted with the location changed at four sets of positions, ±45°, ±15°, ±5°, and ±2°. The test stimulus was a 125–6,000 Hz broadband noise of 1 s at 60 ± 2 dB SPL with a 2 s interval. The N1′–P2′ amplitudes, N1′ latencies, and P2′ latencies of ACC under four positions were evaluated. The influence of electrode sites and the direction of sound position change on ACC waveform was analyzed with analysis of variance. Results suggested that (1) ACC can be elicited successfully by changing the horizontal sound location position. The elicitation rate of ACC increased with the increase of location change. (2) N1′–P2′ amplitude increased and N1′ and P2′ latencies decreased as the change of sound location increased. The effects of test angles on N1′–P2′ amplitude [F(1.91,238.1) = 97.172, p < 0.001], N1′ latency [F(1.78,221.90) = 96.96, p < 0.001], and P2′ latency [F(1.87,233.11) = 79.97, p < 0.001] showed a statistical significance. (3) The direction of sound location change had no significant effect on any of the ACC peak amplitudes or latencies. (4) Sound location discrimination threshold by the ACC test (97.0% elicitation rate at ±5°) was higher than MAA threshold (2.08 ± 0.5°). The current study results show that though the ACC thresholds are higher than the behavioral thresholds on MAA task, ACC can be used as an objective method to evaluate sound localization ability. This article discusses the implications of this research for clinical practice and evaluation of localization skills, especially for children. Frontiers Media S.A. 2022-06-06 /pmc/articles/PMC9207405/ /pubmed/35733932 http://dx.doi.org/10.3389/fnins.2022.908989 Text en Copyright © 2022 Fan, Zhao, Sharma, Valderrama, Fu, Liu, Fu, Li, Zhao, Guo, Fu, Wang and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Fan, Zhi-Tong
Zhao, Zi-Hui
Sharma, Mridula
Valderrama, Joaquin T.
Fu, Qian-Jie
Liu, Jia-Xing
Fu, Xin
Li, Huan
Zhao, Xue-Lei
Guo, Xin-Yu
Fu, Luo-Yi
Wang, Ning-Yu
Zhang, Juan
Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing
title Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing
title_full Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing
title_fullStr Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing
title_full_unstemmed Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing
title_short Acoustic Change Complex Evoked by Horizontal Sound Location Change in Young Adults With Normal Hearing
title_sort acoustic change complex evoked by horizontal sound location change in young adults with normal hearing
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207405/
https://www.ncbi.nlm.nih.gov/pubmed/35733932
http://dx.doi.org/10.3389/fnins.2022.908989
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