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The Impacts of COVID-19 on Musculoskeletal Health

PURPOSE OF REVIEW: Although COVID-19 was originally characterized as a respiratory disease, recent findings have shown lingering side effects in those who have recovered, and much is still unknown about the long-term consequences of the illness. Thus, the potential of unearthing multi-system dysfunc...

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Autores principales: Awosanya, Olatundun D., Dadwal, Ushashi C., Imel, Erik A., Yu, Qigui, Kacena, Melissa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207429/
https://www.ncbi.nlm.nih.gov/pubmed/35723777
http://dx.doi.org/10.1007/s11914-022-00734-x
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author Awosanya, Olatundun D.
Dadwal, Ushashi C.
Imel, Erik A.
Yu, Qigui
Kacena, Melissa A.
author_facet Awosanya, Olatundun D.
Dadwal, Ushashi C.
Imel, Erik A.
Yu, Qigui
Kacena, Melissa A.
author_sort Awosanya, Olatundun D.
collection PubMed
description PURPOSE OF REVIEW: Although COVID-19 was originally characterized as a respiratory disease, recent findings have shown lingering side effects in those who have recovered, and much is still unknown about the long-term consequences of the illness. Thus, the potential of unearthing multi-system dysfunction is high, with current data revealing significant impacts on musculoskeletal health. RECENT FINDINGS: Multiple animal models of COVID-19 infection have revealed significant post-infection bone loss at several different skeletal sites. While how this loss occurred is unknown, this current review discusses the primary bone loss studies, and examines the possible mechanisms of action including: direct infection of bone marrow macrophages or hematopoietic progenitors, a proinflammatory response as a result of the COVID-19 induced cytokine storm, and/or a result of hypoxia and oxidative stress. This review will further examine how therapeutics used to treat COVID-19 affect the skeletal system. Finally, this review will examine the possible consequence that delayed care and limited healthcare accessibility has on musculoskeletal-related patient outcomes. SUMMARY: It is important to investigate the potential impact COVID-19 infection has on musculoskeletal health.
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spelling pubmed-92074292022-06-21 The Impacts of COVID-19 on Musculoskeletal Health Awosanya, Olatundun D. Dadwal, Ushashi C. Imel, Erik A. Yu, Qigui Kacena, Melissa A. Curr Osteoporos Rep Muscle and Bone (A Bonetto and M Brotto, Section Editors) PURPOSE OF REVIEW: Although COVID-19 was originally characterized as a respiratory disease, recent findings have shown lingering side effects in those who have recovered, and much is still unknown about the long-term consequences of the illness. Thus, the potential of unearthing multi-system dysfunction is high, with current data revealing significant impacts on musculoskeletal health. RECENT FINDINGS: Multiple animal models of COVID-19 infection have revealed significant post-infection bone loss at several different skeletal sites. While how this loss occurred is unknown, this current review discusses the primary bone loss studies, and examines the possible mechanisms of action including: direct infection of bone marrow macrophages or hematopoietic progenitors, a proinflammatory response as a result of the COVID-19 induced cytokine storm, and/or a result of hypoxia and oxidative stress. This review will further examine how therapeutics used to treat COVID-19 affect the skeletal system. Finally, this review will examine the possible consequence that delayed care and limited healthcare accessibility has on musculoskeletal-related patient outcomes. SUMMARY: It is important to investigate the potential impact COVID-19 infection has on musculoskeletal health. Springer US 2022-06-20 2022 /pmc/articles/PMC9207429/ /pubmed/35723777 http://dx.doi.org/10.1007/s11914-022-00734-x Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Muscle and Bone (A Bonetto and M Brotto, Section Editors)
Awosanya, Olatundun D.
Dadwal, Ushashi C.
Imel, Erik A.
Yu, Qigui
Kacena, Melissa A.
The Impacts of COVID-19 on Musculoskeletal Health
title The Impacts of COVID-19 on Musculoskeletal Health
title_full The Impacts of COVID-19 on Musculoskeletal Health
title_fullStr The Impacts of COVID-19 on Musculoskeletal Health
title_full_unstemmed The Impacts of COVID-19 on Musculoskeletal Health
title_short The Impacts of COVID-19 on Musculoskeletal Health
title_sort impacts of covid-19 on musculoskeletal health
topic Muscle and Bone (A Bonetto and M Brotto, Section Editors)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207429/
https://www.ncbi.nlm.nih.gov/pubmed/35723777
http://dx.doi.org/10.1007/s11914-022-00734-x
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