Cargando…

Nox2 underpins microvascular inflammation and vascular contributions to cognitive decline

Chronic microvascular inflammation and oxidative stress are inter-related mechanisms underpinning white matter disease and vascular cognitive impairment (VCI). A proposed mediator is nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (Nox2), a major source of reactive oxygen species (ROS)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alfieri, Alessio, Koudelka, Juraj, Li, Mosi, Scheffer, Sanny, Duncombe, Jessica, Caporali, Andrea, Kalaria, Rajesh N, Smith, Colin, Shah, Ajay M, Horsburgh, Karen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207496/ https://www.ncbi.nlm.nih.gov/pubmed/35102790 http://dx.doi.org/10.1177/0271678X221077766

Ejemplares similares

Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment
por: Li, Mosi, et al.
Publicado: (2022)

Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion
por: Kitamura, Akihiro, et al.
Publicado: (2017)

NOX2 and NOX5 are increased in cardiac microvascular endothelium of deceased COVID-19 patients
por: Jiang, Zhu, et al.
Publicado: (2023)

Vascular underpinning of COVID-19
por: Wazny, Vanessa, et al.
Publicado: (2020)

Differential contribution of Nox1, Nox2 and Nox4 to kidney vascular oxidative stress and endothelial dysfunction in obesity
por: Muñoz, Mercedes, et al.
Publicado: (2019)

CRISPR/Cas9-mediated knockout of p22phox leads to loss of Nox1 and Nox4, but not Nox5 activity
por: Prior, Kim-Kristin, et al.
Publicado: (2016)

Different mechanisms underpin the decline in growth of anchovies and sardines of the Bay of Biscay
por: Boëns, Andy, et al.
Publicado: (2023)

Redox signaling, Nox5 and vascular remodeling in hypertension
por: Montezano, Augusto C., et al.
Publicado: (2015)

Editorial: The Cognitive Underpinnings of Anthropomorphism
por: Airenti, Gabriella, et al.
Publicado: (2019)

Pandemic underpins need for SOAR
por: Tankard, Colin
Publicado: (2020)

Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate
por: Burtenshaw, Denise, et al.
Publicado: (2017)

Thermal Requirements Underpinning Germination Allude to Risk of Species Decline from Climate Warming
por: Cochrane, Jennifer Anne
Publicado: (2020)

Arteriolar neuropathology in cerebral microvascular disease
por: Fang, Chuo, et al.
Publicado: (2023)

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease
por: Kalaria, Raj N.
Publicado: (2016)

Nox2 Is Required for Macrophage Chemotaxis towards CSF-1
por: Chaubey, Sanjay, et al.
Publicado: (2013)

Nox
por: Hettche, Thomas, 1964-
Publicado: (1996)

Cell-specific effects of Nox2 on the acute and chronic response to myocardial infarction
por: Sirker, Alexander, et al.
Publicado: (2016)

Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction
por: Murdoch, Colin E., et al.
Publicado: (2011)

Microvascular Pathology and Morphometrics of Sporadic and Hereditary Small Vessel Diseases of the Brain
por: Craggs, Lucinda J.L., et al.
Publicado: (2014)

Function and design of the Nox1 system in vascular smooth muscle cells
por: Yin, Weiwei, et al.
Publicado: (2013)

Nox4 as a novel therapeutic target for diabetic vascular complications
por: Wang, Dongxia, et al.
Publicado: (2023)

Divergent effects of genetic and pharmacological inhibition of Nox2 NADPH oxidase on insulin resistance-related vascular damage
por: Maqbool, Azhar, et al.
Publicado: (2020)

Erratum to: Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction
por: Murdoch, Colin E., et al.
Publicado: (2014)

Fibroblast Nox2 (NADPH Oxidase-2) Regulates ANG II (Angiotensin II)–Induced Vascular Remodeling and Hypertension via Paracrine Signaling to Vascular Smooth Muscle Cells
por: Harrison, Craig B., et al.
Publicado: (2020)

Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo
por: Brewer, Alison C., et al.
Publicado: (2011)

NOX4 downregulation leads to senescence of human vascular smooth muscle cells
por: Przybylska, Dorota, et al.
Publicado: (2016)

Nox2 contributes to hyperinsulinemia-induced redox imbalance and impaired vascular function
por: Mahmoud, Abeer M., et al.
Publicado: (2017)

VEO-IBD NOX1 variant highlights a structural region essential for NOX/DUOX catalytic activity
por: Ward, Josie, et al.
Publicado: (2023)

Small Vessel Disease and Subcortical Vascular Dementia
por: Kalaria, Raj N., et al.
Publicado: (2006)

Inducibility, but not stability, of atrial fibrillation is increased by NOX2 overexpression in mice
por: Mighiu, Alexandra S, et al.
Publicado: (2021)

MRI load of cerebral microvascular lesions and neurodegeneration, cognitive decline, and dementia
por: Wang, Rui, et al.
Publicado: (2018)

Overexpression of NOX2 Exacerbates AngII-Mediated Cardiac Dysfunction and Metabolic Remodelling
por: Hansen, Synne S., et al.
Publicado: (2022)

MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles
por: Marchetti, Micol, et al.
Publicado: (2020)

Nox2 Deficiency Prevents Hypertension-Induced Vascular Dysfunction and Hypertrophy in Cerebral Arterioles
por: Chan, Siu-Lung, et al.
Publicado: (2013)

Regulation of Nox enzymes expression in vascular pathophysiology: Focusing on transcription factors and epigenetic mechanisms
por: Manea, Simona-Adriana, et al.
Publicado: (2015)

The cognitive and neural underpinnings of discourse coherence in post-stroke aphasia
por: Alyahya, Reem S W, et al.
Publicado: (2022)

Island woodiness underpins accelerated disparification in plant radiations
por: Nürk, Nicolai M., et al.
Publicado: (2019)

Nox-2-Mediated Phenotype Loss of Hippocampal Parvalbumin Interneurons Might Contribute to Postoperative Cognitive Decline in Aging Mice
por: Qiu, Li-Li, et al.
Publicado: (2016)

Hydroxysafflor Yellow A Blocks HIF-1α Induction of NOX2 and Protects ZO-1 Protein in Cerebral Microvascular Endothelium
por: Li, Yi, et al.
Publicado: (2022)

NOX, NOX Who is There? The Contribution of NADPH Oxidase One to Beta Cell Dysfunction
por: Taylor-Fishwick, David A.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_sh3q4scnv36kt436cupjvh4ia5