Neutrophil-Specific Knockdown of β2 Integrins Impairs Antifungal Effector Functions and Aggravates the Course of Invasive Pulmonal Aspergillosis

β2-integrins are heterodimeric surface receptors that are expressed specifically by leukocytes and consist of a variable α (CD11a-d) and a common β-subunit (CD18). Functional impairment of CD18, which causes leukocyte adhesion deficiency type-1 results in an immunocompromised state characterized by...

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Detalles Bibliográficos
Autores principales: Haist, Maximilian, Ries, Frederic, Gunzer, Matthias, Bednarczyk, Monika, Siegel, Ekkehard, Kuske, Michael, Grabbe, Stephan, Radsak, Markus, Bros, Matthias, Teschner, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207500/
https://www.ncbi.nlm.nih.gov/pubmed/35734179
http://dx.doi.org/10.3389/fimmu.2022.823121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207500/
https://www.ncbi.nlm.nih.gov/pubmed/35734179
http://dx.doi.org/10.3389/fimmu.2022.823121

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