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Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology

Parkinson’s disease (PD) is characterized by the formation of Lewy bodies (LBs) in the brain. LBs are mainly composed of phosphorylated and aggregated α-synuclein (α-Syn). Thus, strategies to reduce the expression of α-Syn offer promising therapeutic avenues for PD. DNA/RNA heteroduplex oligonucleot...

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Detalles Bibliográficos
Autores principales:	Cao, Qianqian, Luo, Shilin, Yao, Wei, Qu, Youge, Wang, Nanbu, Hong, Jian, Murayama, Shigeo, Zhang, Zhentao, Chen, Jiaxu, Hashimoto, Kenji, Qi, Qi, Zhang, Ji-chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207554/ https://www.ncbi.nlm.nih.gov/pubmed/35784012 http://dx.doi.org/10.1016/j.omtn.2022.05.037

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