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Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials
Bone tumor patients often face the problems with cancer cell residues and bone defects after the operation. Therefore, researchers have developed many bifunctional scaffolds with both tumor treatment and bone repair functions. Therapeutic agents are usually combined with bioactive scaffolds to achie...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207581/ https://www.ncbi.nlm.nih.gov/pubmed/35734197 http://dx.doi.org/10.1016/j.mtbio.2022.100318 |
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author | Yuan, Jiongpeng Ye, Zhaoyi Zeng, Yaoxun Pan, Zhenxing Feng, ZhenZhen Bao, Ying Li, Yushan Liu, Xujie He, Yan Feng, Qingling |
author_facet | Yuan, Jiongpeng Ye, Zhaoyi Zeng, Yaoxun Pan, Zhenxing Feng, ZhenZhen Bao, Ying Li, Yushan Liu, Xujie He, Yan Feng, Qingling |
author_sort | Yuan, Jiongpeng |
collection | PubMed |
description | Bone tumor patients often face the problems with cancer cell residues and bone defects after the operation. Therefore, researchers have developed many bifunctional scaffolds with both tumor treatment and bone repair functions. Therapeutic agents are usually combined with bioactive scaffolds to achieve the “bifunctional”. However, the synergistic effect of bifunctional scaffolds on tumor therapy and bone repair, as well as the interplay between therapeutic agents and scaffold materials in bifunctional scaffolds, have not been emphasized and discussed. This review proposes a promising design scheme for bifunctional scaffolds: the synergistic effect and interplay between the therapeutic agents and scaffold materials. This review summarizes the latest research progress in bifunctional scaffolds for therapeutic applications and regeneration. In particular, it summarizes the role of tumor therapeutic agents in bone regeneration and the role of scaffold materials in tumor treatment. Finally, a perspective on the future development of bifunctional scaffolds for tumor therapy and bone regeneration is discussed. |
format | Online Article Text |
id | pubmed-9207581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-92075812022-06-21 Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials Yuan, Jiongpeng Ye, Zhaoyi Zeng, Yaoxun Pan, Zhenxing Feng, ZhenZhen Bao, Ying Li, Yushan Liu, Xujie He, Yan Feng, Qingling Mater Today Bio Review Article Bone tumor patients often face the problems with cancer cell residues and bone defects after the operation. Therefore, researchers have developed many bifunctional scaffolds with both tumor treatment and bone repair functions. Therapeutic agents are usually combined with bioactive scaffolds to achieve the “bifunctional”. However, the synergistic effect of bifunctional scaffolds on tumor therapy and bone repair, as well as the interplay between therapeutic agents and scaffold materials in bifunctional scaffolds, have not been emphasized and discussed. This review proposes a promising design scheme for bifunctional scaffolds: the synergistic effect and interplay between the therapeutic agents and scaffold materials. This review summarizes the latest research progress in bifunctional scaffolds for therapeutic applications and regeneration. In particular, it summarizes the role of tumor therapeutic agents in bone regeneration and the role of scaffold materials in tumor treatment. Finally, a perspective on the future development of bifunctional scaffolds for tumor therapy and bone regeneration is discussed. Elsevier 2022-06-09 /pmc/articles/PMC9207581/ /pubmed/35734197 http://dx.doi.org/10.1016/j.mtbio.2022.100318 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Yuan, Jiongpeng Ye, Zhaoyi Zeng, Yaoxun Pan, Zhenxing Feng, ZhenZhen Bao, Ying Li, Yushan Liu, Xujie He, Yan Feng, Qingling Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials |
title | Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials |
title_full | Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials |
title_fullStr | Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials |
title_full_unstemmed | Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials |
title_short | Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials |
title_sort | bifunctional scaffolds for tumor therapy and bone regeneration: synergistic effect and interplay between therapeutic agents and scaffold materials |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207581/ https://www.ncbi.nlm.nih.gov/pubmed/35734197 http://dx.doi.org/10.1016/j.mtbio.2022.100318 |
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