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Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts

Multiple pesticide residue accumulations increase the probability of chronic metabolic diseases in humans. Thus, we applied multi-omics techniques to reveal how the gut microbiome responded to pesticide exposure. Then, we explored how probiotic Lactiplantibacillus plantarum P9 (P9) consumption impac...

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Autores principales: Liu, Wenjun, Li, Changkun, Li, Bohai, Shang, Qingxiang, Han, Zhe, Zhang, Yuan, Liu, Xiufang, Fan, Hui, Zhang, Jiachao, Chen, Yongfu, Zhang, Heping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207661/
https://www.ncbi.nlm.nih.gov/pubmed/35733791
http://dx.doi.org/10.1016/j.isci.2022.104472
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author Liu, Wenjun
Li, Changkun
Li, Bohai
Shang, Qingxiang
Han, Zhe
Zhang, Yuan
Liu, Xiufang
Fan, Hui
Zhang, Jiachao
Chen, Yongfu
Zhang, Heping
author_facet Liu, Wenjun
Li, Changkun
Li, Bohai
Shang, Qingxiang
Han, Zhe
Zhang, Yuan
Liu, Xiufang
Fan, Hui
Zhang, Jiachao
Chen, Yongfu
Zhang, Heping
author_sort Liu, Wenjun
collection PubMed
description Multiple pesticide residue accumulations increase the probability of chronic metabolic diseases in humans. Thus, we applied multi-omics techniques to reveal how the gut microbiome responded to pesticide exposure. Then, we explored how probiotic Lactiplantibacillus plantarum P9 (P9) consumption impacted the gut microbiota and immune factors after high pesticide exposure. Multi-omics results indicated frequent exposure to pesticides did not alter the composition of the intestinal microbiota, but it did increase the abundance of Lipopolysaccharide in the gut, which might contribute to chronic inflammation. Supplementation with P9 maintained the homeostasis of the gut microbiota and reduced the abundance of pathogens in the high pesticide-exposed subjects. By detecting metabolites, we observed uridine and 5-oxoproline concentrations increased significantly after P9 consumption. Furthermore, P9 alleviated immune factors disorder and promoted pesticide residue excretion. Our findings provide new insights into the application of probiotics for pesticide detoxification, and suggest probiotics as daily supplements for pesticide exposure prevention.
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spelling pubmed-92076612022-06-21 Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts Liu, Wenjun Li, Changkun Li, Bohai Shang, Qingxiang Han, Zhe Zhang, Yuan Liu, Xiufang Fan, Hui Zhang, Jiachao Chen, Yongfu Zhang, Heping iScience Article Multiple pesticide residue accumulations increase the probability of chronic metabolic diseases in humans. Thus, we applied multi-omics techniques to reveal how the gut microbiome responded to pesticide exposure. Then, we explored how probiotic Lactiplantibacillus plantarum P9 (P9) consumption impacted the gut microbiota and immune factors after high pesticide exposure. Multi-omics results indicated frequent exposure to pesticides did not alter the composition of the intestinal microbiota, but it did increase the abundance of Lipopolysaccharide in the gut, which might contribute to chronic inflammation. Supplementation with P9 maintained the homeostasis of the gut microbiota and reduced the abundance of pathogens in the high pesticide-exposed subjects. By detecting metabolites, we observed uridine and 5-oxoproline concentrations increased significantly after P9 consumption. Furthermore, P9 alleviated immune factors disorder and promoted pesticide residue excretion. Our findings provide new insights into the application of probiotics for pesticide detoxification, and suggest probiotics as daily supplements for pesticide exposure prevention. Elsevier 2022-05-26 /pmc/articles/PMC9207661/ /pubmed/35733791 http://dx.doi.org/10.1016/j.isci.2022.104472 Text en © 2022. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Liu, Wenjun
Li, Changkun
Li, Bohai
Shang, Qingxiang
Han, Zhe
Zhang, Yuan
Liu, Xiufang
Fan, Hui
Zhang, Jiachao
Chen, Yongfu
Zhang, Heping
Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts
title Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts
title_full Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts
title_fullStr Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts
title_full_unstemmed Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts
title_short Lactiplantibacillus plantarum P9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts
title_sort lactiplantibacillus plantarum p9 improved gut microbial metabolites and alleviated inflammatory response in pesticide exposure cohorts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207661/
https://www.ncbi.nlm.nih.gov/pubmed/35733791
http://dx.doi.org/10.1016/j.isci.2022.104472
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