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Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial
BACKGROUND: Traditional rural housing in hot, humid regions of sub-Saharan Africa usually consists of single-level, poorly ventilated dwellings. Houses are mostly poorly screened against malaria mosquitoes and limited airflow discourages the use of bednets resulting in high indoor transmission. This...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207857/ https://www.ncbi.nlm.nih.gov/pubmed/35725486 http://dx.doi.org/10.1186/s13063-022-06461-z |
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author | Mshamu, Salum Mmbando, Arnold Meta, Judith Bradley, John Bøjstrup, Thomas Chavalier Day, Nicholas P. J. Mukaka, Mavuto Okumu, Fredros Olotu, Ally Pell, Christopher Deen, Jacqueline Knudsen, Jakob Lindsay, Steven W. von Seidlein, Lorenz |
author_facet | Mshamu, Salum Mmbando, Arnold Meta, Judith Bradley, John Bøjstrup, Thomas Chavalier Day, Nicholas P. J. Mukaka, Mavuto Okumu, Fredros Olotu, Ally Pell, Christopher Deen, Jacqueline Knudsen, Jakob Lindsay, Steven W. von Seidlein, Lorenz |
author_sort | Mshamu, Salum |
collection | PubMed |
description | BACKGROUND: Traditional rural housing in hot, humid regions of sub-Saharan Africa usually consists of single-level, poorly ventilated dwellings. Houses are mostly poorly screened against malaria mosquitoes and limited airflow discourages the use of bednets resulting in high indoor transmission. This study aims to determine whether living in a novel design house with elevated bedrooms and permeable screened walls reduces malaria, respiratory tract infections, and diarrhoea among children in rural Tanzania. METHODS/STUDY DESIGN: This is a household-randomized, controlled study in 60 villages in Mtwara, Tanzania. A total of 550 households are randomly selected, 110 of which are allocated a novel design house and 440 households continue to reside in traditional houses. A dynamic cohort of about 1650 children under 13 years will be enrolled and followed for 3 years, approximately 330 living in novel design houses and 1320 in traditional rural houses. The primary endpoint is the incidence of malaria; secondary endpoints are incidences of acute respiratory tract infections and diarrhoea diseases detected by passive and active surveillance. Exposure to malaria vectors will be assessed using light traps in all study houses. Structural, economic, and social science studies will assess the durability, cost-effectiveness, and acceptability of the new houses compared with traditional housing. Environmental data will be collected indoors and outdoors in study homes to assess the differences between house typologies. DISCUSSION: This is the first randomized controlled trial to assess the protective efficacy of a new house design targeting malaria in sub-Saharan Africa. The findings of this study could influence the future construction of homes in hot and humid zones of Africa. TRIAL REGISTRATION: ClinicalTrials.govNCT04529434. Registered on August 27, 2020 |
format | Online Article Text |
id | pubmed-9207857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92078572022-06-21 Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial Mshamu, Salum Mmbando, Arnold Meta, Judith Bradley, John Bøjstrup, Thomas Chavalier Day, Nicholas P. J. Mukaka, Mavuto Okumu, Fredros Olotu, Ally Pell, Christopher Deen, Jacqueline Knudsen, Jakob Lindsay, Steven W. von Seidlein, Lorenz Trials Study Protocol BACKGROUND: Traditional rural housing in hot, humid regions of sub-Saharan Africa usually consists of single-level, poorly ventilated dwellings. Houses are mostly poorly screened against malaria mosquitoes and limited airflow discourages the use of bednets resulting in high indoor transmission. This study aims to determine whether living in a novel design house with elevated bedrooms and permeable screened walls reduces malaria, respiratory tract infections, and diarrhoea among children in rural Tanzania. METHODS/STUDY DESIGN: This is a household-randomized, controlled study in 60 villages in Mtwara, Tanzania. A total of 550 households are randomly selected, 110 of which are allocated a novel design house and 440 households continue to reside in traditional houses. A dynamic cohort of about 1650 children under 13 years will be enrolled and followed for 3 years, approximately 330 living in novel design houses and 1320 in traditional rural houses. The primary endpoint is the incidence of malaria; secondary endpoints are incidences of acute respiratory tract infections and diarrhoea diseases detected by passive and active surveillance. Exposure to malaria vectors will be assessed using light traps in all study houses. Structural, economic, and social science studies will assess the durability, cost-effectiveness, and acceptability of the new houses compared with traditional housing. Environmental data will be collected indoors and outdoors in study homes to assess the differences between house typologies. DISCUSSION: This is the first randomized controlled trial to assess the protective efficacy of a new house design targeting malaria in sub-Saharan Africa. The findings of this study could influence the future construction of homes in hot and humid zones of Africa. TRIAL REGISTRATION: ClinicalTrials.govNCT04529434. Registered on August 27, 2020 BioMed Central 2022-06-20 /pmc/articles/PMC9207857/ /pubmed/35725486 http://dx.doi.org/10.1186/s13063-022-06461-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Study Protocol Mshamu, Salum Mmbando, Arnold Meta, Judith Bradley, John Bøjstrup, Thomas Chavalier Day, Nicholas P. J. Mukaka, Mavuto Okumu, Fredros Olotu, Ally Pell, Christopher Deen, Jacqueline Knudsen, Jakob Lindsay, Steven W. von Seidlein, Lorenz Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial |
title | Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial |
title_full | Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial |
title_fullStr | Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial |
title_full_unstemmed | Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial |
title_short | Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial |
title_sort | assessing the impact of a novel house design on the incidence of malaria in children in rural africa: study protocol for a household-cluster randomized controlled superiority trial |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207857/ https://www.ncbi.nlm.nih.gov/pubmed/35725486 http://dx.doi.org/10.1186/s13063-022-06461-z |
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