Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation

[Image: see text] As a strategy to inactivate antimicrobial agents after use, we designed a range of ethanolamine derivatives where four of them possessed interesting activity. The ethanolamine moiety facilitates photodecomposition, which in a potential drug will take place after use. Herein, the sy...

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Autores principales: Eikemo, Vebjørn, Holmelid, Bjarte, Sydnes, Leiv K., Sydnes, Magne O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207920/
https://www.ncbi.nlm.nih.gov/pubmed/35653169
http://dx.doi.org/10.1021/acs.joc.2c00681
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author Eikemo, Vebjørn
Holmelid, Bjarte
Sydnes, Leiv K.
Sydnes, Magne O.
author_facet Eikemo, Vebjørn
Holmelid, Bjarte
Sydnes, Leiv K.
Sydnes, Magne O.
author_sort Eikemo, Vebjørn
collection PubMed
description [Image: see text] As a strategy to inactivate antimicrobial agents after use, we designed a range of ethanolamine derivatives where four of them possessed interesting activity. The ethanolamine moiety facilitates photodecomposition, which in a potential drug will take place after use. Herein, the synthetic preparation of these compounds and the mechanism of photoinactivation are described.
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spelling pubmed-92079202022-06-21 Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation Eikemo, Vebjørn Holmelid, Bjarte Sydnes, Leiv K. Sydnes, Magne O. J Org Chem [Image: see text] As a strategy to inactivate antimicrobial agents after use, we designed a range of ethanolamine derivatives where four of them possessed interesting activity. The ethanolamine moiety facilitates photodecomposition, which in a potential drug will take place after use. Herein, the synthetic preparation of these compounds and the mechanism of photoinactivation are described. American Chemical Society 2022-06-02 2022-06-17 /pmc/articles/PMC9207920/ /pubmed/35653169 http://dx.doi.org/10.1021/acs.joc.2c00681 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Eikemo, Vebjørn
Holmelid, Bjarte
Sydnes, Leiv K.
Sydnes, Magne O.
Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation
title Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation
title_full Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation
title_fullStr Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation
title_full_unstemmed Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation
title_short Photodegradable Antimicrobial Agents: Synthesis and Mechanism of Degradation
title_sort photodegradable antimicrobial agents: synthesis and mechanism of degradation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9207920/
https://www.ncbi.nlm.nih.gov/pubmed/35653169
http://dx.doi.org/10.1021/acs.joc.2c00681
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AT sydnesleivk photodegradableantimicrobialagentssynthesisandmechanismofdegradation
AT sydnesmagneo photodegradableantimicrobialagentssynthesisandmechanismofdegradation

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