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Exploring kinase family inhibitors and their moiety preferences using deep SHapley additive exPlanations
BACKGROUND: While it has been known that human protein kinases mediate most signal transductions in cells and their dysfunction can result in inflammatory diseases and cancers, it remains a challenge to find effective kinase inhibitor as drugs for these diseases. One major challenge is the compensat...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208089/ https://www.ncbi.nlm.nih.gov/pubmed/35725381 http://dx.doi.org/10.1186/s12859-022-04760-5 |