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Regional years of life lost, years lived with disability, and disability-adjusted life-years for severe mental disorders in Guangdong Province, China: a real-world longitudinal study

BACKGROUND: To understand the magnitude and spatial–temporal distribution of the regional burden attributable to severe mental disorders is of great essential and high policy relevance. The study aimed to address the burden of severe mental disorders by evaluating the years of life lost, years lived...

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Autores principales: Tan, Wenyan, Chen, Lichang, Zhang, Yuqin, Xi, Junyan, Hao, Yuantao, Jia, Fujun, Hall, Brian J., Gu, Jing, Wang, Shibin, Lin, Haicheng, Lin, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208127/
https://www.ncbi.nlm.nih.gov/pubmed/35725574
http://dx.doi.org/10.1186/s41256-022-00253-3
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author Tan, Wenyan
Chen, Lichang
Zhang, Yuqin
Xi, Junyan
Hao, Yuantao
Jia, Fujun
Hall, Brian J.
Gu, Jing
Wang, Shibin
Lin, Haicheng
Lin, Xiao
author_facet Tan, Wenyan
Chen, Lichang
Zhang, Yuqin
Xi, Junyan
Hao, Yuantao
Jia, Fujun
Hall, Brian J.
Gu, Jing
Wang, Shibin
Lin, Haicheng
Lin, Xiao
author_sort Tan, Wenyan
collection PubMed
description BACKGROUND: To understand the magnitude and spatial–temporal distribution of the regional burden attributable to severe mental disorders is of great essential and high policy relevance. The study aimed to address the burden of severe mental disorders by evaluating the years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) in Guangdong, China. METHODS: We undertook a longitudinal study based on a multicenter database established by the Health Commission of Guangdong, involving a total of 21 prefectures and four economic regions in the Guangdong province. A total of 520,731 medical records from patients with severe mental disorders were collected for 2010–2020. Data were analyzed via an integrated evaluation framework by synthesizing prevalence estimates, epidemiological adjustment as well as comorbidity assessment to develop internally consistent estimates of DALY. DALY changes during 2010–2020 were decomposed by population growth and aging and further grouped by Socio-demographic Index (SDI). DALYs were projected to 2030 by the weighted median annualized rate of change in 2010–2020. RESULTS: In 2010–2020, the average DALYs for severe mental disorders reached 798,474 (95% uncertainty interval [UI]: 536,280–1,270,465) person-years (52.2% for males, and 47.8% for females). Severe mental disorders led to a great amount of disease burden, especially in Guangzhou, Shenzhen, and Foshan cities. Schizophrenia and mental retardation with mental disorders were the two leading sources of the burden ascribed to severe mental disorders. Population growth and aging could be accountable for the increasing burden of severe mental disorders. Economic regions with higher SDI carried a greater burden but had lower annualized rates of change in DALYs. The overall burden of severe mental disorders is projected to rise modestly over the next decade. CONCLUSIONS: The findings urge prioritization of initiatives focused on public mental health, prevention strategies, health resources reallocation, and active involvement of authorities to effectively address the anticipated needs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41256-022-00253-3.
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spelling pubmed-92081272022-06-21 Regional years of life lost, years lived with disability, and disability-adjusted life-years for severe mental disorders in Guangdong Province, China: a real-world longitudinal study Tan, Wenyan Chen, Lichang Zhang, Yuqin Xi, Junyan Hao, Yuantao Jia, Fujun Hall, Brian J. Gu, Jing Wang, Shibin Lin, Haicheng Lin, Xiao Glob Health Res Policy Research BACKGROUND: To understand the magnitude and spatial–temporal distribution of the regional burden attributable to severe mental disorders is of great essential and high policy relevance. The study aimed to address the burden of severe mental disorders by evaluating the years of life lost, years lived with disability, and disability-adjusted life-years (DALYs) in Guangdong, China. METHODS: We undertook a longitudinal study based on a multicenter database established by the Health Commission of Guangdong, involving a total of 21 prefectures and four economic regions in the Guangdong province. A total of 520,731 medical records from patients with severe mental disorders were collected for 2010–2020. Data were analyzed via an integrated evaluation framework by synthesizing prevalence estimates, epidemiological adjustment as well as comorbidity assessment to develop internally consistent estimates of DALY. DALY changes during 2010–2020 were decomposed by population growth and aging and further grouped by Socio-demographic Index (SDI). DALYs were projected to 2030 by the weighted median annualized rate of change in 2010–2020. RESULTS: In 2010–2020, the average DALYs for severe mental disorders reached 798,474 (95% uncertainty interval [UI]: 536,280–1,270,465) person-years (52.2% for males, and 47.8% for females). Severe mental disorders led to a great amount of disease burden, especially in Guangzhou, Shenzhen, and Foshan cities. Schizophrenia and mental retardation with mental disorders were the two leading sources of the burden ascribed to severe mental disorders. Population growth and aging could be accountable for the increasing burden of severe mental disorders. Economic regions with higher SDI carried a greater burden but had lower annualized rates of change in DALYs. The overall burden of severe mental disorders is projected to rise modestly over the next decade. CONCLUSIONS: The findings urge prioritization of initiatives focused on public mental health, prevention strategies, health resources reallocation, and active involvement of authorities to effectively address the anticipated needs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41256-022-00253-3. BioMed Central 2022-06-20 /pmc/articles/PMC9208127/ /pubmed/35725574 http://dx.doi.org/10.1186/s41256-022-00253-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Tan, Wenyan
Chen, Lichang
Zhang, Yuqin
Xi, Junyan
Hao, Yuantao
Jia, Fujun
Hall, Brian J.
Gu, Jing
Wang, Shibin
Lin, Haicheng
Lin, Xiao
Regional years of life lost, years lived with disability, and disability-adjusted life-years for severe mental disorders in Guangdong Province, China: a real-world longitudinal study
title Regional years of life lost, years lived with disability, and disability-adjusted life-years for severe mental disorders in Guangdong Province, China: a real-world longitudinal study
title_full Regional years of life lost, years lived with disability, and disability-adjusted life-years for severe mental disorders in Guangdong Province, China: a real-world longitudinal study
title_fullStr Regional years of life lost, years lived with disability, and disability-adjusted life-years for severe mental disorders in Guangdong Province, China: a real-world longitudinal study
title_full_unstemmed Regional years of life lost, years lived with disability, and disability-adjusted life-years for severe mental disorders in Guangdong Province, China: a real-world longitudinal study
title_short Regional years of life lost, years lived with disability, and disability-adjusted life-years for severe mental disorders in Guangdong Province, China: a real-world longitudinal study
title_sort regional years of life lost, years lived with disability, and disability-adjusted life-years for severe mental disorders in guangdong province, china: a real-world longitudinal study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208127/
https://www.ncbi.nlm.nih.gov/pubmed/35725574
http://dx.doi.org/10.1186/s41256-022-00253-3
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