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Breastfeeding has no protective effects on the development of coronary artery lesions in Kawasaki disease: a retrospective cohort study

BACKGROUND: Kawasaki disease (KD) is a self-limiting vasculitis with an unknown etiology. It has been reported that breastfeeding has a potential protective effect on KD development. However, whether breastfeeding has an effect on the development of coronary artery lesions (CALs) remains unclear. ME...

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Autores principales: Wang, Hongli, Tang, Yunjia, Yan, Wenhua, Xu, Qiuqin, Li, Xuan, Qian, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208131/
https://www.ncbi.nlm.nih.gov/pubmed/35725463
http://dx.doi.org/10.1186/s12887-022-03422-y
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author Wang, Hongli
Tang, Yunjia
Yan, Wenhua
Xu, Qiuqin
Li, Xuan
Qian, Weiguo
author_facet Wang, Hongli
Tang, Yunjia
Yan, Wenhua
Xu, Qiuqin
Li, Xuan
Qian, Weiguo
author_sort Wang, Hongli
collection PubMed
description BACKGROUND: Kawasaki disease (KD) is a self-limiting vasculitis with an unknown etiology. It has been reported that breastfeeding has a potential protective effect on KD development. However, whether breastfeeding has an effect on the development of coronary artery lesions (CALs) remains unclear. METHODS: We retrospectively reviewed the medical records of patients with the main diagnosis of KD hospitalized in our hospital from May 2017 to November 2018. Standardized telephone interviews were carried out to obtain feeding practices before KD was onset. RESULTS: Two hundred and ninety-three (51.6%) were exclusively breastfed, 223 (39.3%) were partially breastfed and 52 (9.2%) were formula fed. There were no significant differences in the characteristics regarding age, gender, incomplete KD, intravenous immunoglobulin (IVIG) resistance, and the laboratory variables among the three groups. With formula feeding as a reference, patients exclusively breastfed and partially breastfed seemed to have a higher incidence of CALs, even after adjusting confounders, but were not statistically significant. After grouping patients who were older than six months into formula feeding, partial breastfeeding for < 2 months, partial breastfeeding for ≥ 2 and < 4 months, partial breastfeeding for ≥ 4 and < 6 months and exclusively breastfeeding based on the length of breastfeeding, the results remained the same (P > 0.05). CONCLUSIONS: Breastfeeding has no protective effect on the development of CALs in KD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-022-03422-y.
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spelling pubmed-92081312022-06-21 Breastfeeding has no protective effects on the development of coronary artery lesions in Kawasaki disease: a retrospective cohort study Wang, Hongli Tang, Yunjia Yan, Wenhua Xu, Qiuqin Li, Xuan Qian, Weiguo BMC Pediatr Research BACKGROUND: Kawasaki disease (KD) is a self-limiting vasculitis with an unknown etiology. It has been reported that breastfeeding has a potential protective effect on KD development. However, whether breastfeeding has an effect on the development of coronary artery lesions (CALs) remains unclear. METHODS: We retrospectively reviewed the medical records of patients with the main diagnosis of KD hospitalized in our hospital from May 2017 to November 2018. Standardized telephone interviews were carried out to obtain feeding practices before KD was onset. RESULTS: Two hundred and ninety-three (51.6%) were exclusively breastfed, 223 (39.3%) were partially breastfed and 52 (9.2%) were formula fed. There were no significant differences in the characteristics regarding age, gender, incomplete KD, intravenous immunoglobulin (IVIG) resistance, and the laboratory variables among the three groups. With formula feeding as a reference, patients exclusively breastfed and partially breastfed seemed to have a higher incidence of CALs, even after adjusting confounders, but were not statistically significant. After grouping patients who were older than six months into formula feeding, partial breastfeeding for < 2 months, partial breastfeeding for ≥ 2 and < 4 months, partial breastfeeding for ≥ 4 and < 6 months and exclusively breastfeeding based on the length of breastfeeding, the results remained the same (P > 0.05). CONCLUSIONS: Breastfeeding has no protective effect on the development of CALs in KD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-022-03422-y. BioMed Central 2022-06-20 /pmc/articles/PMC9208131/ /pubmed/35725463 http://dx.doi.org/10.1186/s12887-022-03422-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Hongli
Tang, Yunjia
Yan, Wenhua
Xu, Qiuqin
Li, Xuan
Qian, Weiguo
Breastfeeding has no protective effects on the development of coronary artery lesions in Kawasaki disease: a retrospective cohort study
title Breastfeeding has no protective effects on the development of coronary artery lesions in Kawasaki disease: a retrospective cohort study
title_full Breastfeeding has no protective effects on the development of coronary artery lesions in Kawasaki disease: a retrospective cohort study
title_fullStr Breastfeeding has no protective effects on the development of coronary artery lesions in Kawasaki disease: a retrospective cohort study
title_full_unstemmed Breastfeeding has no protective effects on the development of coronary artery lesions in Kawasaki disease: a retrospective cohort study
title_short Breastfeeding has no protective effects on the development of coronary artery lesions in Kawasaki disease: a retrospective cohort study
title_sort breastfeeding has no protective effects on the development of coronary artery lesions in kawasaki disease: a retrospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208131/
https://www.ncbi.nlm.nih.gov/pubmed/35725463
http://dx.doi.org/10.1186/s12887-022-03422-y
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