Central nervous system effects of 5-HT(7) receptors: a potential target for neurodegenerative diseases

5-HT(7) receptors (5-HT(7)R) are the most recently identified among the family of serotonin receptors. Their role in health and disease, particularly as mediators of, and druggable targets for, neurodegenerative diseases, is incompletely understood. Unlike other serotonin receptors, for which abunda...

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Autores principales: Quintero-Villegas, Alejandro, Valdés-Ferrer, Sergio Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208181/
https://www.ncbi.nlm.nih.gov/pubmed/35725396
http://dx.doi.org/10.1186/s10020-022-00497-2
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author Quintero-Villegas, Alejandro
Valdés-Ferrer, Sergio Iván
author_facet Quintero-Villegas, Alejandro
Valdés-Ferrer, Sergio Iván
author_sort Quintero-Villegas, Alejandro
collection PubMed
description 5-HT(7) receptors (5-HT(7)R) are the most recently identified among the family of serotonin receptors. Their role in health and disease, particularly as mediators of, and druggable targets for, neurodegenerative diseases, is incompletely understood. Unlike other serotonin receptors, for which abundant preclinical and clinical data evaluating their effect on neurodegenerative conditions exist, the available information on the role of the 5-HT(7)R receptor is limited. In this review, we describe the signaling pathways and cellular mechanisms implicated in the activation of the 5-HT(7)R; also, we analyze different mechanisms of neurodegeneration and the potential therapeutic implications of pharmacological interventions for 5-HT(7)R signaling.
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spelling pubmed-92081812022-06-21 Central nervous system effects of 5-HT(7) receptors: a potential target for neurodegenerative diseases Quintero-Villegas, Alejandro Valdés-Ferrer, Sergio Iván Mol Med Mini-Review 5-HT(7) receptors (5-HT(7)R) are the most recently identified among the family of serotonin receptors. Their role in health and disease, particularly as mediators of, and druggable targets for, neurodegenerative diseases, is incompletely understood. Unlike other serotonin receptors, for which abundant preclinical and clinical data evaluating their effect on neurodegenerative conditions exist, the available information on the role of the 5-HT(7)R receptor is limited. In this review, we describe the signaling pathways and cellular mechanisms implicated in the activation of the 5-HT(7)R; also, we analyze different mechanisms of neurodegeneration and the potential therapeutic implications of pharmacological interventions for 5-HT(7)R signaling. BioMed Central 2022-06-20 /pmc/articles/PMC9208181/ /pubmed/35725396 http://dx.doi.org/10.1186/s10020-022-00497-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mini-Review
Quintero-Villegas, Alejandro
Valdés-Ferrer, Sergio Iván
Central nervous system effects of 5-HT(7) receptors: a potential target for neurodegenerative diseases
title Central nervous system effects of 5-HT(7) receptors: a potential target for neurodegenerative diseases
title_full Central nervous system effects of 5-HT(7) receptors: a potential target for neurodegenerative diseases
title_fullStr Central nervous system effects of 5-HT(7) receptors: a potential target for neurodegenerative diseases
title_full_unstemmed Central nervous system effects of 5-HT(7) receptors: a potential target for neurodegenerative diseases
title_short Central nervous system effects of 5-HT(7) receptors: a potential target for neurodegenerative diseases
title_sort central nervous system effects of 5-ht(7) receptors: a potential target for neurodegenerative diseases
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208181/
https://www.ncbi.nlm.nih.gov/pubmed/35725396
http://dx.doi.org/10.1186/s10020-022-00497-2
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