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Regulation and function of elF2B in neurological and metabolic disorders

Eukaryotic initiation factor 2B, eIF2B is a guanine nucleotide exchange, factor with a central role in coordinating the initiation of translation. During stress and disease, the activity of eIF2B is inhibited via the phosphorylation of its substrate eIF2 (p-eIF2α). A number of different kinases resp...

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Detalles Bibliográficos
Autores principales:	Hanson, Filipe M., Hodgson, Rachel E., de Oliveira, Madalena I. Ribeiro, Allen, K. Elizabeth, Campbell, Susan Gerarda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2022
Materias:	Molecular Bases of Health & Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208314/ https://www.ncbi.nlm.nih.gov/pubmed/35579296 http://dx.doi.org/10.1042/BSR20211699

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